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Lucine Health Sciences and Hormones Matter are dedicated to improving healthcare with more research and better health and medication data.

Closed clinical trials data, positive publication bias and sometimes outright fraud, have made medical-decision making perilous and costly. According to the BMJ when published reports in peer-reviewed journals are re-analyzed to include the unpublished data for FDA-approved drugs, a whopping 93% of the outcomes changed.  Additional studies found that fully 50% of common therapeutic interventions are completely unproven. In women’s healthcare only 30% of Ob/Gyn Clinical Practice Guidelines are based on evidence, much of it biased. Worse yet, PNAS  reports that in 2012, that one in every 10,000 medical articles published was retracted, 67% of the retractions were due to misconduct with the vast majority (43%) for fraud or suspected fraud. We think that is unacceptable, and so should you.

Data matter. One cannot practice medicine, make personal healthcare decisions or business decisions without accurate data. We’re working to change that, one study at a time.

Health Data for the Real World

Want to know if a medication works, go to the patient. Want to know if a treatment has side-effects, go to the patient. We bring the patient back into the research equation with large, direct-to-patient medication and treatment research. We began with a series of women’s health studies and are expanding into general health, but central to each of our studies, is the belief that the patient is key.

Take a few minutes to complete a survey about health, hormones, medications and life in general. Take as many health surveys as are applicable and share this page with your friends. All surveys are anonymous and completely voluntary. Your data matter.

Health Surveys for Real Women

Real Risk Study: Birth Control and Blood Clots

Blood clots are a serious complication of hormonal contraceptive use and can be disabling or even fatal. Although some risk factors are already known, such as a family history of blood clots, increasing age, and smoking, many women who have suffered blood clots while on hormonal contraception have none of these risk factors. We believe that a deeper understanding of additional medical and lifestyle factors affecting a woman’s risk is needed. If you or a loved one have suffered from a blood clot while using hormonal contraception, participate in this study and help provide women with information they need about their personal level of risk with these medications.

Why I Use Oral Contraceptives Survey

Oral contraceptives (birth control pills) are prescribed for a myriad of reasons unrelated to pregnancy prevention. Sometimes they work; sometimes they don’t. Wouldn’t it be nice if we knew which brands of birth control pills worked for which conditions? Better yet, wouldn’t it great if we could avoid the pills that didn’t work, made a particular condition worse or had a higher than average side-effect profile? Take this survey and help us figure it out. Your data may save another woman’s life and health. Phase 1 of this study is complete and the results are currently being analyzed. Please stay tuned for the release of phase 2 of this study, and phase 1 results.

The Hysterectomy Survey

By the age of 60 one in three women will have had a hysterectomy. Hysterectomy is one of the most common surgical procedures for a range of women’s health conditions. For some conditions, hysterectomy works wonders. While for other conditions it is only nominally successful. The purpose of the hysterectomy survey is to learn more about why hysterectomy works for some women’s health conditions and not others. We’d also like to learn more about the long-term health affects of hysterectomy – does a woman who has had a hysterectomy have a higher or lower risk of other health conditions? Take this survey and help improve women’s health.

The Gardasil Cervarix Survey

Women and their physicians need more data about the side-effects of the HPV vaccines, Gardasil and Cervarix. There is a lack of data about who is at risk for adverse events and whether certain pre-existing conditions increase one’s risk for an adverse event. There is also a lack of data about the long-term health effects of these vaccines. The purpose of this survey is to fill that data void; to learn more about the risks for, and nature of, the adverse events associated with each of the HPV vaccines, Gardasil and Cervarix. Take this survey and help improve women’s health options.

The Lupron Side Effects Survey

Leuprolide, more commonly known as Lupron, is the GnRH agonist prescribed for endometriosis, uterine fibroids or cysts, undiagnosed pelvic pain, precocious puberty, during infertility treatments, and to treat some cancers. It induces a menopause like state stopping menstruation and ovulation. It’s widespread use for pain-related female reproductive disorders such as endometriosis or fibroids is not well supported, with very few studies indicating its efficacy in either reducing pain or diagnosing or treating endometriosis or other pelvic pain conditions. Conversely, reports of safety issues are mounting, especially within the patient communities. The Lupron Side Effects Survey was designed to determine the range, rate and severity of side-effects and adverse events associated with Lupron use in women. Phase 1 of this study is complete and the results are currently being analyzed. Please stay tuned for the release of phase 2 of this study, and phase 1 results.

The Fluoroquinolone Antibiotic Side Effects Survey

Patients and their physicians need more data about the side-effects of the fluoroquinolone antibiotics. The purpose of this survey is to fill that data void; to learn more about the risks for and nature of adverse events associated with each of the fluoroquinolone antibiotics, Cipro, Levaquin, Avelox and others. This will be the first of a series of studies on fluoroquinolone reactions. Anyone who have been given one of these medications, whether a reaction developed or not, and/or the parents or other family members of children too young or patients too incapacitated to take the survey for themselves, should take this survey.

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  1. I had a laparoscopic removal of my uterus and left ovary 2 weeks ago, before that I had an endometrial ablation where she found fibroids and removed them in September and in December I had 2 very light periods with really bad PMS symptoms, so I called the gynecologist and made an appointment. On the day of my appointment she came in asked about my periods in December after I told her she stood up and said”Well, you gave it the old college try so we’re just gonna give you a hysterectomy “, patted me on my shoulder and walked out. The visit with her literally lasted 5 minutes. I was expecting an exam or an ultrasound, since she has the machine in her office or maybe some bloodwork to see if she could figure out what was going on with me, but, none of that happened. Her scheduler came in and says to me “Does Monday work for you”. Obviously my answer was no because I needed more than 3 days to prepare. Even though I was confused and scared I trusted my Doctor and her diagnosis. So the surgery was scheduled for February 21st. From the day of my office visit till the day of surgery there were no kind of preoperative tests ran at all, even though I have Rheumatoid and osteoarthritis and hypothyroidism, still I trusted my doctor and didn’t question it. The day of the surgery came and afterwards she went to my husband who was waiting in the waiting room and told him that she removed my uterus and left ovary because she found a cyst and scar tissue that she believed to be from prior cysts bursting and that I had endometriosis and gave him a card and told him to call right away if there were any concerns or questions. On the papers from the hospital there’s a list that tells you to call if this or that happens and 3 of the things in the list were, severe swelling and pain in the legs, extensive bruising and swelling of my belly. I was experiencing all 3 so we called the after hours number like we were instructed, left a detailed message about everything I was experiencing and we heard nothing till the following Monday when we got a call from one of her office staff telling me that she called me in compression socks. While on the phone I tell her about the bruising and swelling in my belly and all the pain I was in, because she didn’t prescribe me any pain medication, instead she doubled the dosage that my PCP gives me for my RA and because she did that I ran out of my pain meds, when I told her this she said there was nothing she could do because its illegal for her to write me a script for pain, so I literally suffered in pain for the next few days as the bruising got worse and my belly continued to swell. By the time I decided to go to the ER because I was either being completely ignored or they were very rude and dismissive, I looked as though I was 5 months pregnant and had just been hit by a mack truck. The ER did a CT scan and found fluid in my soft tissues and fluid in my pelvic area, so I had to make another appointment with my gynecologist before the week was up. At this appointment I was seen by her PA and again no examination, she just looked at my belly from 2 feet away and diagnosed me with a blood clotting issue and that I need to find a hematologist or better yet just go see my rheumatologist because it’s going to take me twice as long to heal, forgetting that they had a list of all of my medications and that I am not nor have I been on RA meds in quite some time because my Rheumatologist is in the process of trying to get me started on xeljanz and very rudely said” At this point the only thing I can do is prescribe you enough pain meds to get you through till you see your PCP” at no time did she discuss the hospital findings, in fact I had no idea until I went to my PCP who had the records from the hospital. He asked if they did an ultrasound at the gynecologist office or followed up in any way on the hospital’s findings I told him no and about the PA at the gynecologist office diagnosing me with a blood clotting disorder from 2 feet away with no bloodwork or anything, he then told me that the air in my soft tissues could cause an air embolism that could kill me and they needed to be paying close attention to the fluid in my pelvic area and since the gynecologist office didn’t ordered labs to check my blood for the supposed clotting issue.Fast forward to my 2 week post OP appointment with my surgeon, which by the way was the first time I’d seen or talked to her since right before surgery , I told her what my PCP said and her only concern was why I went to see my PCP and why he ordered the bloodwork. After that she then started to act defensively and after discussing a few things I brought up what she’d told my husband after my surgery at the hospital and she completely changed her story and said that she never said any of that, she said that she told him I had adenomyosia and also informed me that there was extensive scar tissue on my bowels so she removed that as well. None of that was ever said to me or my husband at anytime after the surgery, and since then it’s been nothing but a nightmare. Almost 3 weeks post operative and I still look as though I’ve been hit by a mack truck, my vagina is swollen and purple from bruising even though there was nothing touched in that area and my belly is still swollen.

  2. I cannot get into the fluro antibiotic survey. Says it’s closed. I think I’m dealing with this toxicity andcwould love to take a survey.

  3. i am a man whod like to stop female human castration or hysterectomy and oopherectomy. my own aunty who had two children and firoids was told that her uterus ovaries and fallopian tubes had to be removed. dissatisfied she consulted an ayurveda physician and went on special diet.she went back to her gynaecologist who did the bloody castration. because she was told that she might develop ovarian cancer. she was cured but she was never happy with the removal of her ovaries and said she became old because of it. this was an indirect loss of female identity. she was about 46 years old. she died at the arms of the man she loved but she died of a heart attack at age 67roughly. she had pressure but eventual cause of death was cardiac arrest. she was never haappy with the loss of her ovaries. my question is did her doctor save her from ovarian cancer and eventually kill her of a heart attack. she never suffered from cardiac problems. this is probably happening to millions of women worldwide. there is nothing that the human barstard will never try. when is this going to end. thank you for reading

  4. I had drug induced hepititus after taking a round of ciprofloxcan for a cold…They had to perform
    a bone marrow extract to determine what I had..This was about 5 years ago..I am doing fine
    today, except I have been told by several doctors to not take any generic drugs for any reason.
    I almost died from the problem. My liver on a scale of 40 being nonfunctional..I was at 39.
    I have reported the issue to the FDA and there is no recourse for me or much concern about
    the medicine giving me hepitius.

    1. Edward, since we are no longer running the fluoroquinolone survey, would you like to share your story/experience in a blog post? That way others will read it and have the information they need to make more informed medical decisions.

  5. I still have lots of abdominal pain after I have had a full hysterectomy, 2 separate surgeries. I had severe endometriosis that they found during my second surgery where they had to open up my full abdomen to remove the endometriosis. I was told that it had adhered to the wall of my abdomin but the doctors all said that it should be taken care of. I still have lots of abdominal pain and this has been a real eye opener for me. What tests should be done to find out if they got it all, I feel like they did not remove it all. If anyone has any suggestions please please let me know. Thank you

  6. I have been to 2 doctors , diagnosis hyper/hypo diagnosis,recently Hishimoto. My weight started 135lbs,now150lbs, labs sometimes 0.00 and 0.02 and back down 🙁 l also have multiple sclerosis. My endocrinologist,always says not to worry,orders labs every 6 weeks and adjust levothyroxine.This has been going on for 10 months. Is my doctor doing enough? The way I feel,I repeatedly tell him but Im wonder if there is more he can do for me 🙁 Thank YOU

    1. The MS symptoms may be related to low T3 levels, we have some research on the subject on this blog under thyroid and demyelination. Also consider joining a group called ThyroidChange – they are fantastic. They have a Facebook group and website.

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