The study, conducted by researchers from the University of Chicago, Illinois, was rather unique in its approach. Researchers cultivated prostate stem cells from young, disease-free men and then conducted a series of both in vitro and in vivo exposure tests. In the in vitro tests they exposed the human cells, in culture, to the various levels of hormones over differing periods. With the in vivo tests, however, the researchers took those same human prostate progenitor cells and grafted them to host rats. The host rats were then exposed to the different hormones for different time periods. Hormones tested included: native testosterone, estradiol and BPA, the environmental estrogen that mimics native estradiol. In both series of experiments researchers were interested in the timing and length of hormone exposure on prostate carcinogenesis. What they found was striking.
Male prostate tissue, though dependent on testosterone for development, is also susceptible to native and environmental estrogens. Both types of estrogen receptors are present. Moreover, the timing and duration of estrogen exposure impacts prostate health health. Specifically, treatment of the host rodents for 1-4 months with native testosterone plus estradiol produced a relatively small incidence of cancer, only 13%. Treatment of the host rodents with BPA, however, increased the rate to 33-45%, with higher rates of carcinogenesis linked to longer exposures.
This study provides further evidence that early developmental exposure to environmental estrogens negatively affects male prostate health.
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This post was published originally on Hormones Matter on January 10, 2014.