Exploring Brain Differences: Male v Female

Print Friendly, PDF & Email

The human brain is a truly amazing organ. It controls body temperature, blood pressure, heart rate and breathing; takes in an infinite amount of information about the world using our senses; coordinates our physical movement when walking, talking, standing or sitting; and allows us to think, dream, reason and experience emotions.

And while the brain, like your mother, loves her children – male and female – the same, she loves them differently. One reason for this difference may have to do with the brain structure.

For starters, males have larger brains (and heads) on average than women, even when accounting for differences between male and female height and weight. The male brain is typically about ten percent larger than the female brain. Men also have approximately 6.5 times more gray matter than women. Women, however, have about 10 times more white matter than men (source: Carey) do and women’s brains neurons are more densely packed especially on the cortex of the brain (the command and control center for language and communication).

Researchers believe that men tend to think with their gray matter, which is full of active neurons while women tend to think with the white matter (source: Haier), which consists more of connections between the neurons (source: Witelson). It’s believed these differences between grey and white matter and density may allow a woman’s brain, while smaller in size, to work faster than a man’s, and may account for some of differences in how men and women think, feel and behave (source: Hotz).

Despite noticeable sex differences in brain structure and function, neither the density of women’s neurons, or the size of a man’s brain, are reliable predictors of intelligence. Although the extra mass does give males more processing power, this doesn’t make men more intelligent. Rather, scientists believe the reason for the increased brain mass (source: Shaywitz)  is to accommodate the bigger body mass and muscle groups of the male (source: Shaywitz).

Apart from white matter, how else do females compensate for the difference in size and processor speed? Using imaging studies, scientists have concluded that men and women access different sections of the brain when performing the same task. In one study, men and women were asked to sound out different words. Men relied on just one small area on the left side of the brain to complete the task, while the majority of women used areas in both sides of the brain, indicating that there is more than one way for the brain to arrive at the same result.

Researchers have long believed men to be sharply left-brain dominant (source: Baron-Cohen), while women were believed more evenly balanced between left and right-brain processing (source: Shaywitz). This may explain why women often have better communication skills and emotional intelligence than men, and why men can sometimes have trouble picking up on emotional cues unless they’re clearly verbalized – making for tricky communications between the sexes.

Because women tend to have a larger deep limbic system than men (source: Shaywitz), they’re more in touch with their feelings and are better at expressing their emotions. This makes women better at connecting with others, but unfortunately may also contribute to higher rates of depression. (source: Karolinska Institutet).

Brain structure has also proven important in the treatment of Traumatic Brain Injury (TBI). Research on veterans who’ve experienced (TBI) indicates that based on the location of neurons, brain injuries affect men and women differently (source: Bramlett and Dietrich). The differences in progesterone levels also account for some differences.

Another structural difference is the size of the inferior-parietal lobule, which controls numerical brain function. It is larger in males, and has been thought to account for the consistent male advantage on mathematical standardized tests. However, a few studies have demonstrated that the gender gap in mathematical skills may be subject to our perceptions and expectations. In one study, girls’ math scores improved when they were told that the exam was gender-neutral, while white men’s scores on the same test dropped when they were told the scores would be evaluated against Asian men’s scores. (source: Murphy).  This suggests that the situation is more fluid than just structural differences.

Sex differences in spatial skills are among the largest of the cognitive gaps. For decades researchers attributed this difference to the fact that the parietal region is thicker in the female brain, making it harder for them to mentally rotate objects. However, the actual size of the skill gap is much smaller in children than in adults. Evidence suggests that in addition to the difference in thickness of the parietal region, other factors may have greater explicatory power. One is culture. Boys are exposed to and have more visuospatial interests – building, throwing, navigating, shooting – than girls. The other is chemical. Evidence suggests that the early though relatively small spatial skill gap in small children is influenced by prenatal testosterone (soruce: Kucian). It is as yet unclear whether the widening divergence in spatial skills is influenced by chemical processes or because as males and females grow older the practice different skills.

In a followup, I will explore chemical differences in male and female brains that would explain differences between the sexes.


American Academy of Neurology. “Men More Likely to Have Problems With Memory and Thinking Skills.” ScienceDaily. April 18, 2008. (Sept. 16, 2008) http://www.sciencedaily.com /releases/2008/04/080416152000.htm

Baron-Cohen, Sasha. Essential Difference: Men, Women and the Extreme Male Brain. Penguin, 2003

Bombardieri, Marcella. “Summer’s remarks on women draw fire.” Boston Globe. Jan. 17, 2005. (Sept. 16, 2008) http://www.boston.com/news/local/articles/2005/01/17/summers_remarks_on_women_draw_fire/

Bramlett, Helen, Dietrich, W Dalton. Pathophysiology of Cerebral Ischemia and Brain Trauma: Similarities and Differences. Journal of Cerebral Blood Flow & Metabolism (2004) 24, 133–150; doi:10.1097/01.WCB.0000111614.19196.04

Bryner, Jeanna. “Why Men Dominate Math and Science Fields.” LiveScience. Oct. 9, 2007. (Sept. 16, 2008) http://www.livescience.com/health/071009-women-science.html

“Company News: Mattel Says It Erred; Teen Talk Barbie Turns Silent on Math.” New York Times. Oct. 21, 1992. (Sept. 16, 2008) http://query.nytimes.com/gst/fullpage.html?res=9E0CE7DE103AF932A15753C1A964958260

Crenson, Matt. “Remarks by Harvard President Supported by Some Experts.” Associated Press. Feb. 28, 2005. (Sept. 16, 2008) http://www.livescience.com/strangenews/ap_050228_summers.html

Douglas, Kate. “Cherchez la difference. For years, war has raged over the emotional differences between men and women. Now brain imaging may settle the matter — or will it?” New Scientist. April 27, 1996. (Sept. 16, 2008) http://www.newscientist.com/article/mg15020279.100-cherchez-la-diff%E9rence–for-years-war-has-raged-over-the-emotional-differences-between-men-andwomen-now-brain-imaging-may-settle-the-matteror-will-it-kate-douglasreports.html

Haier RJ. Brains, Bias, and Biology: Follow the Data. In Are Sex Differences in Cognition Responsible for the Under-representation of Women in Scientific Careers?, Edited by SJ Ceci * W Williams, APA Books, 2007.

Hoag, Hannah. “Sex on the brain.” New Scientist. July 19, 2008

Karolinska Institutet. “Sex Differences in the Brain’s Serotonin System.” ScienceDaily. Feb. 17, 2008. (Sept. 16, 2008) http://www.sciencedaily.com­/releases/2008/02/080213111043.htm

Kolata, Gina. “Men and Women Use Brain Differently, Study Discovers.” New York Times. Feb. 16, 1995. (Sept. 16, 2008) http://query.nytimes.com/gst/fullpage.html?res=990CE1D8173FF935A25751C0A963958260&sec=&spon=&pagewanted=all

Kucian, Karin. “Gender Differences in Brain Activation Patterns During Mental Rotation and Number Related Cognitive Tasks .” Psychology Science, Volume 47, 2005 (1), p. 112 – 131.

Murphy, Mary. “Signaling Threat: How Situational Cues Affect Women in Math, Science, and Engineering Settings.” Psychological Science, Oct. 2007.

Ripley, Amanda. “Who Says a Woman Can’t Be Einstein?” Time. March 7, 2005. (Sept. 16, 2008)

Rucker, Michael. “9 Differences Between the Male and Female Brain” Brain Fitness for Life. August 13, 2010 http://www.time.com/time/magazine/article/0,9171,1032301,00.html

Shaywitz, B.A., et al. “Sex differences in the functional organisation of the brain for language.” Nature vol 373 (6515) 607 – 9, 1995

Society for Women’s Health Research. “Sex Differences Extend Into the Brain.” ScienceDaily. March 3, 2008. (Sept. 16, 2008) http://www.sciencedaily.com­/releases/2008/02/080229171609.htm

Thompson, Andrea. “Gender Difference in Grammar.” LiveScience. Dec. 9, 2006. (Sept. 16, 2008) http://www.livescience.com/health/061208_gender_grammar.html

Witelson, Sandra. “The Exeptional Brain of Albert Einstein.” The Lancet, Volume 354, Issue 9192, Page 1821, 20 November 1999

York University. “Male and Female Brain Patterns Differ During Reaching.” ScienceDaily. April 14, 2007. (Sept. 16, 2008) http://www.sciencedaily.com­/releases/2007/04/070413212142.htm


Amy Roost’s passion is public health and policy. She earned a BA in political science from George Washington University and an MA in International Affairs from Columbia University in New York. Amy has worked as a press aide for Charles Percy, chairman of the U.S. Senate Foreign Relations Committee, and many non-profit organizations. She served as the Executive Director of the Chaparral Educational Foundation, the Del Mar Schools Foundation and The Thriver’s Network. In 2006, she founded Co-optimize, a business assisting independent bookstores across the country with various business services. She has spent the past several years developing and marketing the company’s proprietary software. Presently, Amy is moving in the direction of social entrepreneurship. As a blogger and marketing strategist, she hopes to speak for others whose voices are not yet being heard in the policy and research arenas.


  1. This is so fascinating. Thank you Amy. Coming from such a male dominated world in the military, this really helps put things into perspective of why I did things differently than the guys or why things effected me emotionally when they just shrugged it off. I think this should be considered in the debate of putting women in combat – not that we can’t overwrite/reprogram ourselves as Elena pointed out, but some women, same with men, are better suited for other missions (don’t get me wrong I know a handful of women who would make kick-ass infantry[wo]men). I guess this could really be appllied to all areas of life, not just the military – just what I think of first given all the recent headlines. When I read this I had quite a few Aha moments. So interesting to see the science of things we joke about or stereotype when it comes to gender differences.

  2. Nurture and environment play a HUGE role. I’ll discuss this in the next article (as well as plasticity.

  3. This is such an interesting article! I realize that women and men have different sized brains, but I almost wonder if we use our brains differently (when sounding out words, for example) because of how we are taught to respond at a young age (parents may discourage boys to cry, for example). The plasticity of the brain is constantly emphasized, leaving me to wonder if the parts of the brain we use for certain tasks are determined by repetition of specific synaptic paths when we were kids. It also makes me wonder if these synaptic paths can be rewired to utilize different parts of the brain when performing tasks.

Leave a Reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.

Previous Story

Research Center Focuses on Gene Mutations for Ovarian Cancer

Next Story

Placental Encapsulation and Postpartum Health

Latest from Brain & Neuro