High Fat Diet, Estradiol and Retinoic Acid

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Research suggests that women consuming diets rich in saturated fat are more likely than men to have fat deposited in their bodies. A recent study offers possible explanations for these differences in fat metabolism and why fat deposits are more abundant after menopause. Although, the study was done on mice, some conclusions can be extrapolated for women.

Obesity is more prevalent in women (61.3 vs. 42% prevalence in men) and correlates with a higher risk for type 2 diabetes and cardiovascular disease. Fat deposition or adiposity is common before premenopause and after menopause  in women who consume the Western high fat diet.  Two metabolites of Vitamin A  may be responsible. These metabolites retinaldehyde (Rald) and retinoicacid (RA) regulate cell differentiation and metabolism in adipose and other tissues. Low-autocrine RA generation by the cytosolic enzyme family aldehydedehydrogenase-1 (Aldh1a1, -a2, and -a3) stimulates adipogenesis -the birth of fat.

It was shown that in humans, therapeutic RA doses can cause RA syndrome demonstrating increased adiposity. RA is produced primarily by visceral fat (VF) – fat that accumulates around internal organs. RA is also produced in subcutaneous fat.  Both the high fat and the hormone estradiol induced Aldh1 expression in mice, possibly directly through estrogen receptor sites. The authors hypothesized that adipose tissue responds to the high fat diet and estradiol by producing RA. RA in turn increases adipogenesis or the increase in fat creation.  Increases in RA generation and dysregulation of Aldh1 in mouse and human adipose are regulated by diet (high fat diet, leads to fat production) and estradiol. Experiments showed that fat cells in female mice lacking the enzyme could produce proteins that use fat for heat, meaning the fat in these females was burned away rather than stored.

These results suggest that a high fat diet and/or lack of estradiol mediate visceral fat formation through a sex-specific enzyme, the autocrine Aldh1 switch. With this switch, high fat feeding induces fat accumulation by RA instead of the usual lipolysis.  Researcher saw a similar pattern in the adipose cells gathered from obese women.

Experiments on genetically modified mice in which the enzyme was removed showed that female mice stayed lean, especially in the abdominal area, even when they continued to eat a lot of fat. Males without the enzyme also developed less fat, but the effect was far less significant than in females. In the absence of estradiol, ovariectomized female mice had increased expression of the enzyme, suggestive of increased RA generation. These experiments highlight an indirect role for estradiol in adipose regulation.  Estradiol suppresses the enzyme’s activity, which might help explain why postmenopausal women with decreased estradiol in their bodies tend to accumulate fat in their bellies. Higher estradiol concentrations were sufficient to protect female mice from both hormonal and, partially, diet-induced obesity.

This means that estradiol suppresses activation of the obesity-inducing hormone, and as estradiol concentrations decline towards menopause, the visceral fat starts to grow.

What is clear is that a high-fat diet over-rides our natural fat-burning molecules and activates the enzymes that lead to the accumulation of visceral fat. Estradiol keeps these enzymes in check but when estradiol declines, all bets are off.

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3 Comments

  1. Lots of interactions between nuclear receptors exist…so it could be the case. It’s good to hear about the benefits of estrogens…..

  2. Great article. I can’t help but think this is the pattern for fibroid growth too. Long ago, I read some research indicating a dysregulated RA pathway was associated with fibroid tissue growth. Would be great to dig around and see if that is true.

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