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Endocrine Disruptors Impact Women’s Health

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What Are Endocrine Disruptors?

The hormones in our bodies are regulated by the endocrine system and they impact a number of bodily functions, including metabolism, growth, and development. An endocrine disruptor is a chemical that disturbs the way the endocrine system normally functions, thereby interfering with the way hormones and the body functions, as well.

How Do Endocrine Disruptors Impact Women’s Health?

Scientists have found links between endocrine disruptors and a number of health problems in women. Since most studies have only tested animal responses, scientists cannot conclude that these compounds have the same impacts on humans, but most believe that they do.

The following are only some of the health issues that have been linked to endocrine disrupting chemicals:

Precocious Puberty Possibly Due to Endocrine Disruptors

The early onset of puberty may be due to endocrine disrupting chemicals that are pervasive in the environment. The Journal of the American Academy of Pediatrics has found environmental toxins to be a possible explanation for precocious puberty.

While scientists are unsure if the early onset of puberty is due to endocrine disruptors or childhood obesity, it is important to note that endocrine disruptors also seem to cause insulin resistance, which can lead to weight gain.

Vaginal Cancer from Endocrine Disruptors

Unfortunately, there have been human cases that have shown a direct link between endocrine disruptors and the development of vaginal cancer.

Women took diethylstilbestrol (DES) to prevent miscarriages and morning sickness, only to find that this chemical caused their daughters to develop cancer, according to the Environmental Protection Agency. Scientists are still not exactly sure why DES caused vaginal cancer.

Endocrine Disruptors Tied to Breast Cancer

The EPA also acknowledges correlations between endocrine disruptors and certain cancers, such as breast cancer. A study published in Environmental Health Perspectives found environmental toxins increase breast cancer by affecting the regular development of breasts and mammary glands.

The Yale University School of Medicine bolsters this research, showing that endocrine disruptors increase a woman’s risk of breast cancer, particularly if she is exposed to such chemicals during embryonic development.

Endocrine Disruptors Impact Ovaries

The McLaughlin Center for Population Health Risk Assessment in Canada cited the increased risk of ovarian cancer from exposure to environmental toxins, such as pesticides and herbicides, noting that hormone levels seem to impact such outcomes.

The journal, Endocrine Reviews, reported that women with polycystic ovarian syndrome (PCOS) have higher levels of endocrine disruptors (specifically BPA) in their systems. PCOS is a disorder in which women, during their reproductive age, develop small cysts on their ovaries (in most cases). PCOS may impact a woman’s menstrual period, resulting in less frequent periods or none at all, and can make it difficult for a woman to become pregnant.

Uterine Disorders and Endocrine Disruptors

Endocrine disruptors have been found to reprogram genes in the uterus to grow uterine leiomyoma, or uterine tumors. Although these tumors are benign, they may cause heavy menstrual bleeding and/or lead to infertility.

The American Journal of Epidemiology has found links between the use of hair relaxers and uterine leiomyomata, suggesting that hair relaxers, used by many women, have endocrine disrupting chemicals.

The Society of Toxicology reported findings that mice exposed to high levels of genistein, a phytoestrogen found in soy products, developed uterine cancer later in life.

This same organization has shown connections between endometriosis, or the development of endometrial cells outside of the uterus, and endocrine disruptors, notably TCDD, a dioxin. The study found that endometrial cells do not properly respond to progesterone hormones when disrupted by TCDD, which can lead to endometriosis and sometimes infertility.

The Yale School of Medicine has found that endocrine disruptors block gene expression in the uterus, thereby disrupting the proper development of the uterus, which can lead to cancers, endometriosis, and infertility.

Endocrine Disrupting Chemicals Can Cause Infertility

Concentrated levels of hormone-mimicking chemicals can stop ovulation, just as contraceptive pills do, according to The Oxford Journals.

Polybrominated diphenylethers, chemicals used in fire retardants, are linked to cases of infertility. The Society of Toxicology has shown this chemical also reduces thyroid-stimulating hormones (THS) in pregnant women, which can negatively impact fetal brain development.

When Do Endocrine Disruptors Impact a Woman?

Most scientific findings emphasize that exposure to endocrine disruptors during rapid developmental periods, such as gestation, is more detrimental to a woman’s health than exposure at other times. In fact, the Federation of American Societies for Experimental Biology reported that endocrine disruptors often target the genes responsible for the development of an organism, interfering with the proper development of that organism.

Of course, this doesn’t mean that endocrine disruptors stop affecting us once we’re grown. The very chemicals that cause breast cancer have also been found to lessen the effectiveness of cancer fighting drugs. This is because most of the drugs used to treat breast cancer are made to reduce endogenous estrogens – which usually stimulate the cancer. While endocrine disruptors are just as effective as endogenous estrogens in stimulating the cancer, endocrine disruptors are not hindered by these drugs.

How Do We Limit Our Exposure to Endocrine Disruptors?

Endocrine Disruptors impact us every day, but we can limit the amount of toxic chemicals we absorb into our bodies by being aware of what these chemicals are and where they can be found. A good rule of thumb is to start cutting back on the processed goods in your life. If you have difficulty reducing the consumption of processed goods, just start with a few items and continue from there.

Not only do we ingest endocrine disruptors when we swallow pthalates in medication coatings, but we also wear them on our faces in the form of toxic cosmetics and contaminate our water sources with chemical toxins in widely used herbicides. Determine what are safe substitutes, like kitchen cosmetics or safe pesticide alternatives. Start small, choose wisely, and stay abreast of known endocrine disruptors.

Further Reading on Lucine:
Endocrine Disruptors in Personal Products:
Toxic Cosmetics
Kitchen Cosmetics
Is Your Deodorant Linked to Breast Cancer?
Phthalates in Medication Coatings
Endocrine Disrupters in the Environment:
Milk, it Does a Body Good?
Early Onset of Puberty
Could This be a Contributor to Weight Gain?
Chemical Toxins in Commonly Used Herbicides
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Toxins in Cosmetics – Contaminants in Your Personal Care Products

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In the US alone, women spend 50 billion dollars on cosmetic products annually. Each day women smear anti-aging, anti-blemish, cover-up, foundation, powder and more on our faces and bodies in the name of beauty. The FDA does not monitor toxins in cosmetic and personal products because we don’t ingest it; however, our skin is the largest organ in our body and absorbs chemicals directly into the bloodstream faster than if it were digested. The digestive system has a natural process to filter toxins, whereas the epidermis acts more like a sponge. This will be the first in a three part series.

We are what we eat AND what we wear.

What are these nasty chemicals lurking in our beauty and bath products, how do we avoid them and most importantly how do we make changes in legislation to protect us?

There are over 10,500 ingredients in personal care products, but the most common and most dangerous are:

Please click on the chemical name for more information.

  • Cosmetic Toxin – Triclosan – used as an antimicrobial in soaps and hand sanitizers. Triclosan is a known hormone disrupter and provides a suitable environment for the emergence of antimicrobial drug-resistant bacteria.
  • Cosmetic Toxin – Synthetic Musks – used to create scents. Did you honestly think, ‘Midnight Jasmine Hummingbird Orchestra Love Song’ was bottled in a lovely, toxin-free field? The chemicals galaxolide and tonalide are used to make synthetic scents, but also bind to and  stimulate human estrogen receptors and have been shown to affect androgen and progesterone receptors. Tonalide increases the proliferation of estrogen-responsive human breast cancer cells and has been identified as a photosensitizer, a chemical that becomes more toxic when exposed to sunlight on the skin. It has also been linked to liver toxicity.
  • Cosmetic Toxin – Formaldehyde/Formaldehyde-Releasing Preservative (FRP) – A preservative found in nail polish, eyelash glues, hair gels, hair-smoothing products like Brazilian keratin treatments. FRPs do not have to be listed as an ingredient and can be found in personal care products including baby shampoos, soap and body washes. Formaldehyde is recognized as a known human carcinogen by the United States Department of Health and Human Services and the International Agency for Research on Cancer and has been linked to leukemia. Common ingredients likely to be contaminated with formaldehyde or FRPs include: quaternium-15, DMDM hydantoin, imidazolidinyl urea, diazolidinyl urea.
  • Cosmetic Toxin – 1,4-dioxane – Commonly seen as, “sodium laureth sulfate” on shampoo and soaps is used as a foaming agent. It is listed by the California Environmental Protection Agency as a suspected kidney toxicant, neurotoxicant and respiratory toxicant. Other ingredients likely to be contaminated: PEG-100 stearate, polyethylene, ceteareth-20.
  • Cosmetic Toxin – Hydroguinone – Used as a skin lightener and considered one of the most dangerous toxins in cosmetics. Hydroguinone is also found as an impurity in ingredients in facial and skin cleansers, facial moisturizers and hair conditioners. The Environmental Working Group (EWG) found the ingredient tocopheral acetate, and any ingredient with “toco” in the root, is at risk for contamination. Hydroguinone decreases the production of melanin pigments in the skin and simultaneously increases exposure to UVA and UVB rays, thus increasing skin cancer risks.
  • Cosmetic Toxin – PhthalatesUsed to hold color and scents and aren’t usually listed except for in nail polish. A loophole in regulations allows phtalates to be added to fragrances (and therefore almost every cosmetic and personal care product) without being added to the label. Extensive research suggests that phthalates disrupt hormonal systems by reducing the level of sex hormones. Exposure in pregnant women has been linked to shortened distance between the anus and genitals of male babies indicating feminization occurred during genital development. Exposure in adult human males is associated with poor sperm quality and infertility. In women, phthalates have been shown to cause an increase of breast tumor cells and reduces the effectiveness of anti-estrogen treatments against tumors.
  • Cosmetic Toxin – Parabens Used in products to prevent growth of microbes. “Parabens,” actually describes several chemicals with similar molecular structure, but the most common to cosmetic products are: ethylparaben, butylparaben, methylparaben and propylparaben. Parabens have been linked to cancer, endocrine disruption, reproductive toxicity, immunotoxicity, neurotoxicity, and skin irritation.
  • Cosmetic Toxin – Lead and other heavy metals – Metals including arsenic, mercury, aluminum, zinc, chromium, and iron have been found in lipstick, foundation, whitening toothpaste, eyeliner and more; both as intentional ingredients and as contaminants. Titanium dioxide and zinc oxide are often used in sunscreens (I will get into the dangers of sunscreen in a separate post), foundation, concealer, and diaper rash ointments. Iron oxides, aluminum, and chromium are used as a colorant in make-up. Color additives like D&C Red 6, may contain contaminants including arsenic, lead, and mercury. Zinc is used in moisturizers, shampoos and foundations. Heavy metal poisoning in the body can have a variety of adverse health concerns including neurotoxicity, endocrine disruption, birth defects, cancer, and more.
  • Cosmetic Toxin – NitrosaminesAn impurity and, therefore, not a labeled ingredient. Nitrosamines is a known impurity in 53 ingredients and virtually every cosmetic and personal care product including baby products, sunless tanning lotion and pain relief salves. They are actually created in products when nitrates and various amino acids are combined. Specifically, when diethanolamine (DEA) or triethanolamine (TEA), used to adjust the pH of products, are used in products with preservatives that break down into nitrates. Numerous studies have linked nitrosamines to cancer. They are listed by the EPA, International Agency for Research on Cancer, the US National Toxicology Report on Carcinogens and the California Prop 65 as chemicals known to cause cancer or birth defects. And if that wasn’t severe enough, nitrosamines are linked to endocrine disruption, developmental or reproductive toxicity, immunotoxicity,  neurotoxicity and systemic toxicity.

So, you buy organic and natural products to protect yourself and your family, right? Well, more bad news: In the world of cosmetics the words natural, herbal, and even organic have no legal definition. Unfortunately, companies slap an organic sticker on products and then raise the price for unsuspecting consumers more often than not. The only way to truly protect your family is to make your own personal care products or research the products you buy. The good news is the EWG has created an electronic database analyzing 70,547 products and 2,912 brands of these dangerous products. The EWG’s Skin Deep database is an amazing tool to protect both your health and your wallet.

Furthermore, we can take action. First, stop buying products containing these chemicals. Second, spread the word. Not only are you saving someone’s health and potentially life, but you are taking away more customers, eventually forcing these companies to change their ingredients. Third, join or start a campaign to force legislation and regulations to protect the consumer. Organizations like the Environmental Working Group and The Campaign for Safe Cosmetics are dedicated to awareness and change, and have tools for consumers to lobby for change.

Photo by  ehensley, Creative Commons

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