reproductive hormones

Hysterectomy and Brain Health

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Studies abound showing how the endogenous estrogens, estradiol mainly, improve memory and other cognitive functions. New research demonstrates there is an even more basic connection between the female reproductive organs – the uterus and ovaries – and the brain. The monthly menstrual cycle may control iron levels in body and also in the brain. Women who have a hysterectomy before reaching natural menopause may be at higher risk of neurodegenerative diseases such as Azheimer’s and Parkinson’s due to the increased peripheral and brain iron levels post hysterectomy.

Iron and Brain Health

Iron is an essential element for health. Both iron deficiency and excess are associated with brain pathology. In the developing brain, too little iron causes neurological impairment with significant cognitive and neuromuscular deficits. As we age, iron accumulation in the brain is also problematic and linked to neurodegenertive disorders. In part because women menstruate, they have naturally lower levels of peripheral (body) iron than men. Researchers believe that the menstrual flushing of excess iron may be in part responsible for delaying the brain iron accumulation that has been linked to early Alzheimer’s and Parkinson’s in men.

In a study published in the journal Neurobiology of Aging, researchers investigated what effect premenopausal hysterectomy had on brain iron levels. From a sample (n = 93) of healthy older, male and female volunteers, ages 47-80 years, researchers used a specialized MRI to image brain iron levels.

What they found was quite interesting. Women who had hysterectomy before reaching natural menopause had significantly higher iron levels in the white matter of the frontal cortex compared to women who reached menopause naturally. The hysterectomy group, also had higher iron levels in the other brain regions tested but those differences were not large enough to reach statistical significance. Brain iron levels in the hysterectomy group were similar to those of men, who have naturally higher iron levels in the brain and who often succumb to the neurodegenerative diseases at a much earlier age. The researchers speculated that the observed white matter iron accumulation could be a precusor to the grey matter iron accumulation observed in neurodegenerative diseases such as Alzheimer’s and Parkinson’s.

Brain Basics

White matter in the brain consists of the oligodendrocytes – a type of cell that forms what is called the myelin sheath. Myelin is the insulation that protects the axons of the neuron (in the brain) or nerve (in the body) to allow rapid conduction or messaging across the brain or to the body.  Myelin is like the plastic coating around the electrical wiring in your house. If the coating is too thick, conduction is blocked. If the coating is frayed or too thin, electrical sparks fly everywhere. Iron is a critical component of healthy myelin, too much or too little impairs signal conduction – brain messaging.

neuron

Grey matter, on the other hand, is where the unmyelinated portion of neurons – the dendrites and cell bodies – are located. These are brain regions responsible for learning, memory, emotion, sensory perception and motor control. Cells in this part of the brain rely on chemical signaling to translate information. After the dendrite receives and the cell body translates a message, it sends the signal down the myelinated axon to its target.  Iron accumulation, either in the white or grey matter would impact brain function. Iron accumulation specifically in the frontal white matter region would impact all higher order cognitive function.

What This Means

The research is still in its early stages. An observed connection between menstrual blood loss and peripheral or brain iron stores though apparent, may not represent the total picture. It is quite likely that hormones associated with reproductive health, altered by the hysterectomy, also play a role in iron regulation.  Initial research connecting the hyperandrogenic and metabolically dysregulated state of women with PCOS is  associated with increased iron stores, as is general and cancer related inflammation, and genetics. Nevertheless, this study speaks to the critical need for more research about the long-term consequences of hysterectomy. Reproductive hormones regulate more than just reproduction. Removing the organs that synthesize these hormones has health consequences far beyond reproduction. It’s high time we begin addressing this.

If you have had a hysterectomy, be sure to take The Hysterectomy Survey.

Author’s note:  I would like to thank David Wiseman Ph.D., M.R.Pharm.S.
Founder, International Adhesions Society (IAS) for introducing me to this exciting new research.

I’m Sexy and I Know It, Sometimes – Sexual Attraction Chemistry

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Have you, or possibly your partner, ever wondered if there really was a link between your menstrual cycle and sexual attraction? Perhaps you have noticed that during certain times of the month something is not quite right and whatever it is, it seems to affect your ability to concentrate. Scientists have as well.

Evolution, the Menstrual Cycle, and Sexual Attraction

Since the dawn of humankind, women have been programmed to think and act in such a way that helps us find the perfect mate with the best genes to make the best babies; survival of the fittest. However, the conditions and interactions are not as clear-cut today as they were during caveman times. Women are educated and have careers. We work hard and we play harder. In other words, we might be too busy to think of finding a man and having children, at least on a conscious level.

Researchers have found that reproductive hormones are still at play when it comes to how we feel about certain situations, view the world, and interact with others. During the week before ovulation, women have improved memory, perhaps to signify the right time to find “The One,” but also to help you make better decisions and navigate your environment. Near ovulation, women may have a heightened sense of smell, possibly to sniff out potential toxins. Additionally, several studies have shown that women who are in the fertile window tend to dress and feel more attractive as compared to other times in their cycles. A major drawback to this process is that some women may be highly sensitive to to the cyclic rise and fall of their hormones and experience negative mood symptoms, increased food cravings, and susceptibility to stress, particularly during the premenstrual phase.

Oral Contraceptives and Sexual Attraction

What about the pill? Oral contraceptives (OCs) contain synthetic hormones that may also affect women’s social behavior and psychological functioning. In my own research, I have found that women who are on the pill show greater attraction toward current and potential mates across all phases of the cycle. Naturally, this could be due to the simple fact that women using OCs expect to have more sex than those who are not. However, we also found that an increase in androgens, a side effect of the pill, was significantly related to this increase in attraction.

Because of our genetic make-up, women must go through regular shifts in their cognitive abilities, moods, and behavior. In other words, we think, feel, and react differently based on what our hormones are doing. This may translate to women’s approach to relationships, sexual arousal, and motivation to seek out mates. But also, it affects how we work, talk to friends, and deal with our problems.

Does this mean women should plan their activities accordingly? That may be a tad extreme, but maybe it will help both men and women understand why sometimes we are just not in the mood.