Data suggest that at least a third of women with endometriosis may also suffer from migraines. Researchers from Italy found a significantly higher frequency of migraine (38.3%) in women with confirmed endometriosis versus healthy women (15.1%). The onset of migraine was five years earlier (16.4 years versus 21.9) in women with endometriosis and more likely to be a migraine with aura.
The co-occurrence of migraine and endometriosis has only recently begun to be investigated and clues to potential common causes are poorly articulated. There is speculation that migraines cause endometriosis or that endometriosis elicits migraine. Neither has sufficient supporting evidence. The search for clear genetic linkages between migraine and endometriosis is promising but remains in its infancy.
Perhaps we’re looking in the wrong places. As we reported in Endometriosis and Neuropathy, rodent models of endometriosis, suggest a clear neural-uterine connection that initiates endometriotic pain in some but not all. Specifically, some endometriotic tissue sprouts nerve fibers capable of sending pain signals to the brain. Regardless of the cause of the initial endometriotic implants, it is certain that the dynamic hormone biochemistry of the female body would regulate or dysregulate neural firing and pain signaling. The pain of endometriosis though regionally different, could be mechanistically similar to migraine pain. Just a thought.