hysterectomy, hormones and dry eyes

Hysterectomy, Hormones, and Dry Eyes

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Most women know that hysterectomy and ovary removal –castration- leads to a variety of issues – from a dry and painful vagina to hot flashes to mood swings. Heart disease and osteoporosis come to mind as well. However, eye health is not something that is commonly linked to hormones. Since hormone loss and imbalance impacts the eyes, every woman is potentially at risk for dry eyes and even loss of vision.

Dry eye disease can lead to a decreased quality of life, reduced work capacity, and poorer psychological health. Dry eye disease is also associated with a decreased ability to perform activities that require visual attention such as reading and driving a car. I’m all too familiar with the effects of dry eye disease since undergoing an unconsented hysterectomy in 2007. I wrote an article about what happened to me here

I began to have problems with dry eyes within only a few months of the surgery. I made an appointment with my family eye doctor and he told me he saw profound changes in my eyes – especially in my corneas or lenses. He said my eyes had aged a lot since my previous eye exam only a few years prior. They had aged from that of a 40 year old to that of a 60 year old or more. Since I didn’t have diabetes, he said the only reasonable explanation for such rapid changes was hormone loss due to the loss of my ovaries. Eventually, I went on to develop two ulcers on my left cornea. I’m now legally blind in my left eye and can no longer read, work, or drive as I could before.

I had no idea that hysterectomy and castration could lead to dry eyes and loss of vision until it happened to me. In fact, I had no idea how much I needed my tears until I no longer had them.

The eye’s tear film is crucial to eye health and good vision. The tear film is a layer of substances secreted by glands around the eyes and keeps the surface of the eyes lubricated. Tears prevent the cornea from developing erosions, abrasions, and even ulcers which can lead to scarring and vision loss. Tears also provide nutrients for the eyes. And perhaps most important of all, tears reflect or bend light – making vision possible. Poor tear quality can lead not only to eye pain, but impaired vision, and a compromised quality of life.

Most people have seen the Restasis commercial where a woman says her doctor told her she has a disease and then comments that it’s a “big deal”. I agree with her that it’s a big deal to be diagnosed with dry eye disease. Restasis was the first prescription dry eye drug to be FDA approved and remains the only prescription drop on the market that is meant to help a person to make more of their own tears. I have to say though that it’s an expensive eye drop ($200 plus) and it takes several months to really begin to work –  if even then. Many patients taking Restasis continue to need supplementation with artificial tears too. So, not making your tears is not something that is easily remedied.

As many as 70% of those diagnosed with dry eye disease may actually
have Meibomian Gland Disease or “MGD”. I’ve actually been diagnosed with MGD myself. MGD occurs when the oil glands in the eyelids, responsible for producing oil, become clogged and/or dry up. This is a serious condition that causes loss of vital eye protection. Meibomian glands are the oil-producing glands located in both the upper and lower eyelids and they slowly release oil into the tear film. This oil helps to stop the water in the tears from evaporating and prevents dry eyes.

When my cornea specialist tested the quality of my tears by using Schirmer’s test (paper strips inserted into the eye), he found them to be the consistency of toothpaste. That’s obviously not good, so he prescribed an eyelid wash for me to use twice a day and he also recommended I purchase a special cloth which is heated and placed over the eyes to help moisten the glands in the eyelashes. Treating dry eye disease and MGD is very time-consuming to say the least.

Knowing about the link between hormones and dry eye disease is especially important for any woman who is interested in undergoing LASIK surgery since this can permanently affect nerve function of the eye’s clear surface or cornea and worsen dry eye problems. Before undergoing LASIK surgery, any woman who has undergone hysterectomy and castration should be sure to tell her eye doctor about any dry eye condition so special tests can be performed  to determine if the eyes are moist enough for laser vision correction or not.

It should be noted that many medications may cause or worsen dry eye problems too. Diuretics, antidepressants and bladder control medications are all commonly prescribed for women, and yet, they very much contribute to dry eyes. So, any dry eye condition should be discussed with all doctors prescribing these and any other medications.

Dry eye disease is a painful and life-changing situation to be sure, but there are steps a woman can take to help increase tears. Improving the Omega-3-lipid component of the tears leads to better lubrication since the eye surface has an oily film to begin with. A study published in the American Journal of Clinical Nutrition analyzed data from an ongoing women’s health study which indicated that women who ate a daily intake of Omega-3s EPA and DHA in a natural triglyceride form reduced the risk of dry eye disease by up to 66%. I’ve been taking Omega-3s EPA and DHA for years and I think it most definitely has helped.

There’s also been a good amount of research done by Dr. David A. Sullivan that points to success with testosterone supplementation in helping to relieve dry eye disease.  Dr. Sullivan is a Ph.D. graduate of Dartmouth Medical school, an Associate Professor in the Department of Ophthalmology at Harvard Medical School and a Senior Scientist at the Schepens Eye Research Institute. During the past 32 years, his research has focused upon the interrelationships between sex, sex steroids and dry eye disease and has led to authorship on over 200 scientific articles and 10 patents, as well as to the development of potential therapies for aqueous-deficient and evaporative dry eye disease.

Dr. Sullivan’s research indicates that a testosterone deficiency causes meibomian gland dysfunction, tear instability, and evaporation of tears. Therefore, he suggests that eye drops containing testosterone may be a safe and effective way to treat dry eye disease. I haven’t tried testosterone eye drops yet, but I’m very interested. My cornea specialist has routinely prescribed topical azithromycin which is the most commonly prescribed MGD treatment in the U.S. Its use is off-label though since it has not been specifically approved by the FDA for patients with MGD. This particular antibiotic is thought to be effective because of its anti-inflammatory and anti-bacterial actions, which may suppress the MGD-associated inflammation and growth of lid bacteria.

Study findings at Schepens Eye Research may help lead to broader use of topical azithromycin as an FDA-approved on-label treatment of MGD and its associated evaporative dry eye disease.

Please visit my website for more information regarding the link between hormones and eye health here.

This post was published previously in October 2014.


Robin has a B.S. in English and has worked as both a teacher and a writer. Her passion since undergoing an unconsented hysterectomy in 2007 is researching and educating women about the adverse consequences of hysterectomy and ovary removal and also the alternatives. Robin spends most of her time now advocating, writing and blogging about hysterectomy and women's healthcare. Follow her on Twitter @jiggaz31 and on Facebook at www.facebook.com/hysterectomyconsequences


  1. Hi Robin, I found your article when trying to find out the effect of hrt on dry eyes. I returned to hormone therapy and it was drying my eyes out. I was trying to find out if it is the estradial or the progesterone that does it. Also you mentioned the pellets and I was wondering if the pellets work differently and do not dry the eyes. I understand that testosterone helps with dry eye. I have an eye doctor, Dr Neil Desai, in St pete Fl. He does a procedure where he squeezes the meiobiam glands then does a mild laser surrounding the eye and then squeezes the glands again. It has worked in unblocking my meobiam glands. thought you might want to know about that.

  2. Wow Gina, you have truly suffered with many post-hysterectomy issues. I’m so sorry… I’ve encountered a lot of issues too, so that’s a big reason I started doing research and writing articles. I’m happy to hear that the information in my article was helpful to you. Thank you for taking the time to comment here. It’s shameful that doctor don’t seem to understand the link between hormones and eye health.

    What’s helped me more than anything else is getting bioidentical hormone pellets inserted about every 3 months. The pellets work somewhat similar to the way ovaries work – although nothing is every going to be the same as having our own hormone-producing ovaries. Pellets might be something to consider…

    You might also want to consider looking into bioidentical creams. I used those for a while too. They’re messy though and can irritate the skin. It’s probably for the best that you can no longer tolerate Premarin because it is made from horse pee and is not really any good for women. The doctor who performed my unconsented hysterectomy prescribed Premarin for me too, but I quit taking it when I realized what it’s made from. Plus, I was not tolerating it very well.

    If interested (since you have many issues in addition to problems with your eyes), you can read all of my article on Hormones Matter by clicking on “Meet the Writers” and then clicking on my name. You can also find a lot of information on my website @ http://www.hysterectomyconsequences.com

  3. Your article was so useful to me…I had to have an emergency total hysto in 2006…due to severe endometriosis and bleeding for over 16 wks straight…after trying everything but blood transfusion which I didn’t want to do..my Dr left did surgery and left 1 ovary because the endo scarring was not as severe on the one ovary..now my ovary has died…I’m now 41 and the last year and a half of my life has been miserable..I have the worst hot sweats and night sweats…I fill like I’m about to loose my mind emotionally..and I’m driving my husband and boys crazy..chronic fatigue and pain in my body constantly..I have osteoporosis and my teeth are literally shattering in my mouth…I didnt realize that my vision loss in the last 6 months could also be associated with my hormone issues..I now can’t read at all with out strong readers on and cant be outside without sunglasses on and my husband is scared to let me drive because my vision has become so bad…I thought the dryness was just allergies..My health has dropped so drastically in the last 6 months…I have now had to file for disability because I cant work…most days I’m unable to even get out of bed…I was on the highest dose of Premarin for several years..now I cant even take meds orally because this has caused old GI problems to arise…In process of going to compound pharmacy hoping and praying for any type of relief…I wish I would have had someone to talk to about this…like with your experiences…I would never have had it done..I have a 13 yr old at home to still take care of…and he spends more time taking care of me…Thanks for your article…its been more helpful than my own doctors. Would love any advice you could give….Sincerely BEYOND FRUSTRATED-

  4. Hi Roxie, I’m happy to hear the information in my article was helpful to you, but sorry to hear about your experience with hysterectomy and loss of ovarian function. It’s beyond me why doctors don’t know about the link between hormones and eye health. It’s shameful!

    While I don’t know for sure that your Optic Neuropathy is linked to loss of hormones, I think it’s a good possibility since the loss of estrogen accelerates aging of the optic nerve.

  5. this information has been quite helpful to me as I have had dry eye issues since age 34 – a long time to not realize this growing problem is basically due to having had first a partial hysterectomy followed by the death of my ovaries.. Thank you for this article – I know why I haven’t been able to wear contacts for the past 4 years! Not one eye doctor has explained this. I wonder if my sudden onset Optic Neuopathy can be attributed to this as well? I was tested for MS in 2006 with negative results..

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