As published on this web site previously, we have scientific evidence that two girls and one boy were shown to be thiamine deficient (TD) after Gardasil vaccination. On the other hand, a girl who had similar symptoms to these three had not received the vaccine and her laboratory test proved that she also had TD. On the face of this information, it suggests that the vaccination has nothing to do with the illness of these individuals. In a previous post, however, I have suggested that the vaccine is a “stress factor”, given to an individual in a state of marginal, or even asymptomatic thiamine deficiency, thus exacerbating the first appearance of symptoms. In this light, medications and other vaccines may also be considered stress factors and evoke or exacerbate a previously asymptomatic thiamine deficiency. There are a number of facts that need to be seen collectively in order to understand the hypothesis that follows. In order to make this clear I am going to present the material under subheadings.
What Does Thiamine do in the Body?
All simple sugars that we take in our diet are broken down to glucose, the primary fuel of the brain. This oversimplified fact has long been used to suggest that taking sugar is the way to meet energy demands in the body. It is, in fact, an extremely complex chemical process which is well beyond the scope of an article like this. It can, however, be simplified by comparing glucose, as a fuel, to gasoline in a car.
Gasoline + Oxygen + Spark Plug = Energy + (ash/oxides)
Glucose + Oxygen + Thiamine = Energy + (ash/oxides)
Each one of these equations represents combustion, a combination of fuel with oxygen. Because combustion is always incomplete, waste products (oxides) are formed and must be got rid of as waste. It is obvious that combustion of gasoline without oxygen and spark plug, or glucose without oxygen and thiamine, will not occur. What is not quite so obvious is the fact that an excess of gasoline causes choking of the engine, black smoke from the exhaust pipe (unburned hydrocarbons) and loss of engine efficiency. This could be referred to as “oxygen/spark plug deficiency” since each of the three components must be present in proper concentration to produce efficient combustion (oxidation). The three component parts, glucose, oxygen and thiamine are the equivalents in the body. An excess of glucose “chokes” the “engines” (mitochondria) that create energy in all of our cells. This particularly applies to the brain because of its high rate of metabolism (energy consumption), thus providing a potential explanation for why the vaccine seems to pick off the brightest and the best students.
The Reptilian Brain and the Limbic Nervous System
All animal brains are built on the same basic principle, a lower, more primitive part and a higher, increasingly complex part. The lower part of the human brain, the limbic system, also known as “reptilian”, computes all the reflex mechanisms by which we automatically adapt to our environment. For example, we sweat when it is hot and shiver when it is cold, both adaptations to the ambient temperature. It also controls our emotional reflexes, represented by body language that we recognize easily. It uses two mechanisms, the autonomic nervous system and the endocrine system.
Autonomic and Endocrine Systems
We have two nervous systems. The one that we use to will our actions is controlled by the upper brain, here described as cognitive. The autonomic nervous system (ANS) automatically controls all the actions required by body organs to meet day- to- day adaptation. It consists of two major branches, known as the sympathetic and parasympathetic components. The sympathetic branch prepares us for mental and physical action while the parasympathetic switches us to a period of rest. As one goes into action, the other one is withdrawn. The endocrine system is represented by a group of glands, each of which produces one or more hormones. These are really messengers that induce actions in the cells to which they are aimed. When either or both of these systems are not functioning in their ordained manner in the brain/body of an individual, we can refer to him/her as maladapted.
Explanation of Symptoms in Reference to Thiamine Deficiency
As explained in previous posts on this web site, the disease known as beriberi occurs as a result of TD. The mother of a Gardasil affected girl had done her own research and had come to the unlikely conclusion that her daughter suffered from beriberi. Red cell transketolase, a blood test used to depict TD, showed that she was correct in her conclusion. Her daughter did in fact have beriberi and has responded, at least partially, to thiamine supplementation. We know, from historical data, that long term beriberi responds slowly to treatment and sometimes not at all, depending on chronicity. Since she has had her symptoms for approximately four years, I think that it would be fair to call this chronic. When the ANS is not functioning properly, it is called dysautonomia (dys, meaning abnormal: autonomia refers to the ANS). Beriberi in its early stages is the prototype for dysautonomia, the commonest effect being dominance of the sympathetic branch of the ANS.
Published Effects of Gardasil Vaccination
Although many symptoms have been reported related to this vaccination, two resultant conditions have been nominated: POTS (Postural Orthostatic Tachycardia Syndrome) and Cerebellar Ataxia. POTS is one of the many conditions that are described under the heading of dysautonomia and I have already reported in a post that the first case of thiamine dependency was in a six year old boy who had intermittent episodes of cerebellar ataxia, each of which was triggered by a stress episode that included mild infection, mild head injury or inoculation. A critical enzyme that depends on thiamine for its energy producing action was able to function until some form of physical or mental stress was imposed. The existing mechanism was insufficient to meet the energy requirement imposed by the stress.
Sugar, the Autonomic Nervous System and the Liver
New research provides one more clue to our emerging theory of thiamine deficiency in post vaccine and medication adverse reactions. The study: The Autonomic Nervous System Regulates Postprandial Hepatic Lipid Metabolism by Bruinstroop et al. demonstrates the influence carbohydrate intake has on autonomic control of liver lipid metabolism. Triglycerides are measured in a medical laboratory as part of what is known as the “lipid profile”, that includes the various components of cholesterol. The Bruinstroop study found that when the parasympathetic system was deactivated and carbohydrates were ingested, triglyceride levels rose significantly, inducing metabolic dysregulation. Other studies have found stress, combined with diets high in refined carbohydrates can increase blood triglyceride concentrations also inducing metabolic syndrome. Indeed, stress and the concurrent increased sympathetic system activity seem key to metabolic functioning with sugar intake triggering the ill-health.
Interpretation of Technical Language
The work by Bruinstroop and associates was done in rats. To understand what they found, it is necessary to remind the reader that the two branches of the ANS, sympathetic and parasympathetic, work synchronously. As one branch becomes active the other one is withdrawn. This is automatically controlled by the “reptilian” brain, thus enabling us to adapt to the physical and mental changes we encounter on a day -to-day basis. These authors were able to show that abolishing the parasympathetic input to the liver resulted in marked elevation of triglycerides in the blood. This would induce continuation of sympathetic dominance in any “stress reaction” in the animal if it was in a free living state. The effect was modulated by sugar intake. That is, when the animals were fed more, the effects were larger.
Hypothesis: High Sugar Diets Lead to Thiamine Deficiency, A Risk Factor for Adverse Reactions
I am proposing that an excess of carbohydrates in the diet, particularly fructose, results in a mild degree of thiamine deficiency. We know, from studies done as early as 1943 (Williams R D, et al. Arch Int Med 1943;71:38-53), that this results in what is typically called psychosomatic disease, in which a large component is reflected in emotional lability (instability), so common in the modern child and adolescent. Physical symptoms, such as unexplained “pins and needles”, in the hands or feet, may be so slight as to be ignored. The stress of the vaccination or a medication reaction triggers an energy crisis in the “reptilian” brain, specifically evoking autonomic dysregulation, typically with sympathetic system dominance and resulting in beriberi, POTS, or cerebellar ataxia and potentially other syndromes. Perhaps a rise in blood triglycerides as suggested by the Bruinstroop study, indicates the partial crippling of the parasympathetic branch of the ANS and sympathetic dominance. High blood triglycerides might well be a mark of the early stages of underlying autonomic dysregulation and thiamine deficiency and a potential risk factor for adverse reactions to certain vaccines or medications.
A 5th case of post Gardasil thiamine deficiency has been identified; a young woman who developed severe idiopathic hypersomnia, a variant of narcolepsy, post vaccination. The patient is undergoing treatment with success. A full case study will be presented soon.
This article was published on Hormones Matter previously in January 2014.