diabetes sugar thiamine

Thiamine Deficiency and Sugar in Diabetes

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Thiamine is one of the B vitamins and I need to explain its action. To put it as simply as possible, it regulates sugar metabolism in every cell within the body and has a special importance in the brain. About four years ago a researcher in England reported that there was a mild deficiency of thiamine (vitamin B1) in diabetic patients, a disease that affects sugar metabolism. He said that all diabetics should have a supplement of thiamine because he had anticipated that it will prevent complications in this devastating disease. If that is not enough to make a diabetic sit up and take notice I would be very surprised.  I will try to explain this a little further.

A program on PBS television called “The Quiet Revolution” reported that there were 29 million patients in the United States with type two diabetes and as many as 70 million with pre-diabetes, meaning that they were on their way  to contract the disease. If we had 29 million cases of “flu” it would be called a pandemic. Most people with type 2 diabetes have no idea that their health before the onset of the disease is within their own responsibility. Our culture says “go ahead, do what you like, eat what you like, drink what you like; if you get sick, it is just bad luck and you go to one of those clever characters called Dr. who will produce the magic bullet that “cures” you because of the wonders of modern scientific medicine.

Although both types one and two have different causative factors, I want to emphasize very strongly that both types are not purely genetically determined. The genetic risk in type 1 is much greater than in type 2 and is certainly the major component as the underlying cause. Type 2 is much more clearly initiated by dietary indiscretion in a person who might be, shall we say, at genetic risk. Much of our diet today involves the consumption of man-made foods developed by the food industry. Of course, the main drive of this industry is to sell their products and so it appeals to our palatability, a sensory phenomenon that has nothing to do with good nutrition. We all know what pleasure we get from tasting anything that is sweet. Since sweetness sells, it explains why so many man-made foods are laced with sugar, so long thought to be harmless and even good for you by supplying quick energy.

Sweet and Dangerous: Sugar and Thiamine Deficiency

In 1973, John Yudkin, a professor of nutrition in a large London Hospital wrote a book with the title “Sweet and Dangerous”, the result of his many years of research into the dangers of sugar.  He reported that many diseases, including heart disease, were related to its ingestion. As so often happens, this terribly important book was ignored and cholesterol became the demon for the cause of heart disease. Now, 40 years later, many people know that the cholesterol story has been debunked. Because sugar requires vitamin B 1 to metabolize it, in much the same way as gasoline requires a spark plug to burn it, taking sugar on its own in the form of empty calories easily overwhelms the power of thiamine to carry out its function.

That means that you have an imbalance between the calories and the vitamin or a relative deficiency of thiamine. Your daily intake of thiamine may be sufficient for a good diet but not enough to take care of the overload of sugar represented as the bad diet which is so common.  It may easily be accomplished by the consumption of the stuff that we consume in our social activities.  Yes, there is no doubt that it makes the mouth water and the sweetness underlies the joy of the social event but if it is causing widespread disease, I ask you, is it worth it?

The lower part of the human brain is particularly sensitive to thiamine deficiency and because this part of the brain organizes the entire body in its performance of adapting to the environment in which we find ourselves, we easily become maladapted. For example, we may feel cold when it is hot or hot when it is cold, a mistake in sensory input and brain interpretation. The nervous system involved in this reaction is known as the autonomic nervous system and is entirely automatic.  The message from the brain to the heart causes it to accelerate when it is a necessary adaptive need as, for example, running for a bus.  But when this happens spontaneously for no apparent reason at all, we might take this to a physician and tell him that “I have palpitations of my heart”.  Unfortunately the medical focus would be on the heart not on the nervous system that caused the acceleration. For this reason one of the complications in diabetes is called “autonomic neuropathy”, meaning that the autonomic nervous system is disorganized. Thiamine protects diabetics from complications because it improves the ability of our cells to produce adequate energy for function by “burning sugar as brain fuel”.  Think of it as a change of inefficient spark plugs in a car engine.

Thiamine deficiency is sometimes referred to as pseudo (or false) hypoxia because it results in exactly the same symptoms as those from a mild to moderate deprivation of oxygen. Its effect on the lower part of the brain is to make it more reactive to all input signals. When you read a telegram giving you bad news, your eyes send a signal to the brain that has to interpret the meaning of the signal. I refer to the input signals, whether they are physical or mental, as “stress”. Your response to the stress is organized by the lower brain with “advice and consent” from the higher brain. Freud referred to the lower brain as the “id”. It reacts automatically to anything perceived as danger or self indulgence and the upper brain as the “ego” because it either permits or prevents the ensuing action. It is our moral censor.

I have studied the effects of this kind of “high calorie malnutrition” and it is responsible for a huge amount of mental illness and unpredictable bad behavior. It makes the “id” irritable and weakens the “ego” making a person much more likely to act in response to a whim or a nursed grievance.  There is much evidence that it can even affect criminal behavior.  This kind of malnutrition is widespread in America, but I have never seen it discussed in relation to whether the behavior exhibited at inexplicable school shootings is a potential factor. A recent exhibition of “road rage” projected on TV news might just be comprehensible because it was otherwise well beyond civilized behavior. Although this may sound too far-fetched, we have an epidemic of Attention Deficit Disorder, with or without hyperactivity, learning disability and obesity in our children that defies a genetically determined cause. Nature does not make that kind of mistake in so many individuals. Their young brains are irritable and disorganized because of dietary indulgence.

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Image by Bruno from Pixabay.

Derrick Lonsdale M.D., is a Fellow of the American College of Nutrition (FACN), Fellow of the American College for Advancement in Medicine (FACAM). Though now retired, Dr. Lonsdale was a practitioner in pediatrics at the Cleveland Clinic for 20 years and was Head of the Section of Biochemical Genetics at the Clinic. In 1982, Lonsdale joined the Preventive Medicine Group to specialize in nutrient-based therapy. Dr. Lonsdale has written over 100 published papers and the conclusions support the idea that healing comes from the body itself rather than from external medical interventions.


  1. Blood sugar may go up or down with initiating high dose treatment. It is a ” reflection” of what we know of beriberi. It is very much part of “paradox”, otherwise known as “refeeding syndrome”, discussed in full on “Homones Matter”. Benfotiamine is a derivative of thiamine as are all the thiamine derivatives. They have no different action than the original thiamine from which they are ALL derived. They are also known as “open ring” forms, referring to their molecular structure. The ONLY advantage in their use is that they are better absorbed than either thiamine or its water soluble salts. Also their definition as ” fat soluble” refers only to their ability to pass a thiamine molecule through the lipid barrier in the cell membrane into cells . TTFD and its cohorts are disulfides that can deliver thiamine into the cell very easily while Benfotiamine and its cohorts require an enzyme in liver or kidney to get into the cell. Their use should be in the hands of a physician who has done enough library research to understand the chemistry involved. Unfortunately, such physicians are “rare birds” and if you want to “do it yourself”, you must look up the many posts on this website that provide answers to the repetition of questions.

  2. I showed this article to a friend who just found out at 50 years of age that he has Diabetes 1. He does not feel good at all obviously. He wants to take the thiamine after reading this article and I told him about Allithiamine however, I just saw this disclaimer in an article ” diabetics are typically deficient in thiamine however, Dr.Constantini cautions that diabetics should keep a close eye on blood glucose levels while taking high doses of thiamine because he has seen a couple of people whose glucose levels have gone up. Benfotiamine is a synthetic form of thiamine that seems to be particularly effective for diabetes”. This particular article is regarding someone “finding” their long lost energy (CFS) with thiamine and my friend has this energy problem. So, here is my confusion: Benfotiamine does not cross the blood-brain barrier and if low thiamine in the brain is what causes the energy problem then why would benfotiamine work for low energy? One has to use thiamine for this issue, correct? I realize Benfotiaminine can help with other diabetes symptoms but I am talking about energy. Can Allithiamine cause blood glucose to rise? I gave him your protocol of starting low at 50mgs and working up.

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