About TTFD: A Thiamine Derivative

Author: 60 Comments Share:
TTFD thiamine
I recently received notification concerning a “review” posted on HerbCustomer, a commercial website that has been active since February 26, 2010. This so-called “review” was posted on January 16, 2018 by iHerbCustomer entitled “Dangerous allithiamine derivative with no thiamine activity”. The email was posted as well. This person made a potentially libelous statement by referring to me as lying about this thiamine derivative. Its commercial name is Lipothiamine. Its chemical name is thiamine tetrahydrofurfuryl disulfide (TTFD) and this post is to refute the accusations that are made public by this individual.

History of Thiamine Research

Thiamine is the chemical name for vitamin B1 and its deficiency in the diet has long been known as the cause of beriberi. This disease has been known for thousands of years but its underlying cause was only discovered in the closing years of the 19th century. Since beriberi was commonest in the rice consuming cultures, it is not surprising that the major research came from Japan. In the middle of the last century a group of university-based scientists was convened and they wrote a book (Review of the Japanese Literature on Beriberi and Thiamine). This was translated into English, ostensibly because these scientists wished to let people in the West know and understand the pernicious nature of disease resulting from thiamine deficiency. I was fortunate enough to receive a copy of this book from one of the scientists involved. The information in this post is derived from it. Because they were scientists and were well aware of the clinical effects of beriberi, their studies were very extensive. They knew that thiamine existed in garlic and much of their experimentation focused on studies of the garlic bulb. They discovered that there was a natural mechanism in garlic that created a derivative of thiamine and called it allithiamine. Note that this is a naturally occurring substance and the term should be entirely restricted to it.

On a number of occasions I have seen thiamine derivatives being called “The alithiamines” and one commercial product is called Allithiamine with a capital a. The name was given to this naturally occurring product because garlic is a member of the allium species of plants. It can be found in other members of the allium species. Because the Japanese scientists already knew a great deal about the clinical expressions caused by thiamine deficiency, they originally thought that this new derivative might have lost its vitamin dependent activity. They went on to test it in animal studies and found that it had a much greater biologic effect than the original thiamine from which it was derived. They found that it was extremely important that allithiamine was a thiamine disulfide derivative (disulfides are important in human physiology) and they synthesized many different types of thiamine disulfide as well as many non-disulfide derivatives, carefully testing each one for their biologic activity.

What is TTFD?

Without going into the biochemical details, what we now know is that thiamine tetrahydrofurfuryl disulfide (TTFD, Lipothiamine) is, for a number of reasons, the best of the bunch of synthetically produced derivatives and has exciting possibilities in therapy. For example, it has been shown from animal studies that Benfotiamine, a non-disulfide derivative, does not get into the brain whereas TTFD enables absorption of thiamine into the brain where it stimulates energy synthesis. When we take in thiamine, occurring only in our naturally formed food, it is biologically inert. It has to be “activated” within the body that possesses genetically determined mechanisms for its absorption and activation. To cut a technically difficult explanation, let me state that TTFD bypasses this process. It enables thiamine to split away from its disulfide attachment and enter the cells where its activity is required. The concentration achieved in the target cells is much greater than that achieved by the administration of the thiamine from which it was derived.

The Japanese scientists studied the effect of cyanide in mice and found that thiamine propyl disulfide (TPD), a forerunner of TTFD, gave significant protection from the lethal effect of this poison, an incredible discovery that alone should raise eyebrows. They studied this effect and were able to show its mechanism. They also found that it would protect animals from the effect of carbon tetrachloride, a poison that affects the liver. It is using its vitamin actions in a therapeutic manner.

Being myself a consultant pediatrician in a prestigious medical institution, I was able to obtain an independent investigator license (IND) from the Federal Drug Administration, and obtained TTFD from Takeda Chemical Industries in Osaka, Japan, the makers of this product. TTFD is a prescription item in Japan, sold under the commercial name of Alinamin. I have read several publications, showing that it reverses fatigue in both animal and human studies. I was able to study the value of this incredible substance in literally hundreds, if not thousands of patients. Far from being toxic, as this person claims, I never saw a single item that suggested toxicity. Its therapeutic potential is largely untapped in America. This is because the current medical model does not recognize that defective energy metabolism, genetic errors and the nature of stress are the interrelated components whose variable effects in combination are the cause of disease. Do not mistake the use of the word stress, a word that is so commonly used inappropriately. An infection and any form of physical or mental trauma represent a form of stress. It is the ability or the inability to meet the required energy demand to resist that stress that matters in the preservation of health.

Clinical Benefits of TTFD

It is important to understand that the beneficial activity of TTFD is exactly the same as the thiamine from which it is derived. It is the mechanism of its introduction to cells, particularly those in the brain, that enable it to have such an effect on energy metabolism. Because of its strategic position in the cell, thiamine is of vast importance in oxidative metabolism in the complex mechanisms of energy production. There are at least two methods by which thiamine deficiency can be induced. The commonest one is an excess of sugar and fat that overwhelms the capacity of thiamine to conduct the mechanisms involved in energy synthesis. The discovery that thiamine has a part to play in fat metabolism is quite recent. The other one is because of genetic errors involving its biochemical action. However, we now know from a relatively new science called epigenetics that some mistakes in DNA can be overcome by the use of an appropriate nutritional substance like thiamine. The completely non-toxic use of TTFD depends merely on its ability to introduce thiamine into the cells of the body that require its magic. Under these circumstances, the big doses of thiamine are acting like a pharmaceutical by stimulating the missing action. We are not dealing with simple vitamin replacement. This should represent a new era in medicine when nutrient biochemistry takes its place in patient care.

Conclusion

The person that wrote this criticism fails to understand that TTFD and other thiamine derivatives represent a new basic principle of therapy. It recognizes that healing is a function of the body, not the activity of a so-called “healer”. All it requires is the foundation substances needed for repair and sufficient energy to use them. It demands a dramatic change in thinking about health and disease. If you understand the principles involved, it forces the conclusion that the word “cure” is a pipe dream. The only form of pharmaceutical drug that matters is one that safely kills an attacking microbe. Almost all the rest of them merely relieve symptoms and have no effect on the ultimate outcome.

We Need Your Help

Hormones Matter needs funding now. Our research funding was cut recently and because of our commitment to independent health research and journalism unbiased by commercial interests, we allow minimal advertising on the site. That means all funding must come from you, our readers. Don’t let Hormones Matter die.

Yes, I’d like to support Hormones Matter.

Print Friendly, PDF & Email
Share
Previous Article

Repeated Use Doesn’t Make Fluoroquinolones Safe

Next Article

Health Lessons from the Amazon

You may also like

60 Comments

  1. I had duodenal by-pass surgery (roux-en-y duodenojejunostomi) 6 years ago because of an obstruction. Do you think I can reverse a probably quite severe thiamine deficiency by oral TTFD supplementation, or is injections my only chance?

  2. Dear Doctor Lonsdale

    January 2019 by illness began, literally it seemed overnight. I was tired and run down but still worked a full 9 hour day, walking 7km each evening after work. One night i woke up with stomach virus or food poisoning i don ‘t know which, and my spiral started. I had started to get burning in my feet which later progressed to my calfs, leg cramping, extreme weakness, brain cloudiness, headaches and dizziness, diarrhea, stomach pain, I thought I had a terrible virus. This has not resolved since. I have almost every test, scope, colonoscopy, stool testing, blood test, ct scan. All normal with the exception of Vitamin B12 somewhat low at 176. There have been time that I have not been able to keep any food down for weeks at a time, I have lost 30 pounds in the last 4 month. Recently I have tried to take Allithiamine, and Vtiamin B12 I experience even worse dizziness and crawling sensation, with severe brain fog, it almost feels like my brain is burning at the back of my head. My Gastroenterology last visit ended with him suggesting I see a psychiatrist. Please advise, i am desperate for help.

    1. You are on the right track by using vitamin B1 and B12. I am afraid that you are experiencing extreme paradox (there is a significant amount of material on this subject on this form). The trouble with taking vitamins that are badly needed, the first impact is that the symptoms get worse. It is not side effects as is traditional with drugs. You are trying to get from a stage of catabolic to anabolic metabolism and the symptoms that you are trying to treat come back in spades. This paradox may last as long as a month or so You should keep the low-dose of thiamine and B12 until the paradox gives rise to an improvement. You can then exacerbate the dose by titrating to the symptom improvement

  3. Why would allithiamine cause brain fog shortly after ingestion?
    Also worth noting for I’ll share a tidbit for others—80-90% of the time I’ve taken this after dinner/closer to bedtime I’ve slept horribly, waking up many times, like 12+ times. I didn’t realize the correlation as there is an ebb and flow with it with what I believe to be additional factor, other nutrients I’ve taken in during the day, where I am in my menstrual cycle (levels of varying hormones in my body that day) etc. The reason I had not taken during day was due to the brain fog as well as in the past having negative reactions to supplements so I would sleep them off so to speak.
    Thanks!

    1. Becky, please see the post on paradox! Unfortunately it is necessary to adjust your thinking when reading posts on this website. Post after post discusses energy deficiency, particularly in brain cells, as the cause of disease. It represents a new model for the causation of disease. The organs in the body are under the command of the brain for activating and deactivating their function. Energy deficiency in the brain distorts its normal function. causing symptoms that are commonly interpreted as “psychological”. This then affects the function of ALL body organs. Their activity relies on signals to and from the brain through the autonomic (automatic) nervous system to each and every body organ. Energy failure in the brain leads to loss of the necessary signaling process and the failure of an organ is then referred to as “organic disease”. Note that the cause of the organ failure is not in the organ: it is in the brain. That is why many different conditions of the body are really conditions of the brain with the underlying cause being energy failure of the brain. This demands a totally different way of thinking about disease and makes sugar a common villain in our culture because of its destructive effect on thiamine metabolism. Thiamine is vital to brain function because it is the key to energy production. The lower part of the brain that controls the complex functions of the autonomic nervous system is inordinately sensitive to thiamine deficiency. It is this concept that allowed me to treat a 12-year old child with Juvenile Rheumatoid Arthritis using thiamine as the therapeutic agent. This case is described in our book (Lonsdale D, Marrs C. Thiamine Deficiency Disease, Dysautonomia and High Calorie Malnurition) available on Amazon books.

      1. I have recently tried to take Allithimine, I have lots of dizziness, tingling in my head and legs, and brain fog, I almost get a crawling sensation. I have had bouts of severe diarrhea, extreme stomach pain, and nausea so bad upon waking, dry heaves. I was on a 5 day course of Flagyl which made everything so much worse. This all began after a severe stomach virus in January, I have had extensive testing and all doctors say my blood tests are pristine, other than vitamin B12 at 176. I have had scope, colonoscopy, stool sampling, everything test normal. Yet I still remain very ill, with stomach flu like symptoms, the most debilitating the sick dizzy feeling in my head especially about 40 minutes after eating. I am trying to take vitamin B12 but it seems to cause more dizziness and the allithiamine make me even cloudier, please advise. I remain very ill, with no apparent reason and my doctor has suggested I see a psychiatrist, which is so frustrating as prior to the onset in January I walked 7km every day, now I can hardly walk across a room without feeling as though I am going to topple over.

        Desperate for help.

    2. Becky, there is no toxicity from Allithiamine. You are experiencing paradox that you can learn about by hiding the post on this website that explains it. With long term deficiency the brain is in the state of catabolic metabolism and if you try to switch it to anabolic metabolism too quickly it will exacerbate the existing symptoms. Continue with a low dose and the paradox may continue for as long as a month or so.

  4. Dear Dr. Longsdale

    Your work clicks very much with my own experience in my health, as a round of metrodinazole sent me in a spiral of problems.

    Since starting loading on benfotiamine, i experienced a few days of increased muscle/nerve spasms, followed with a slow but consistent improvment of nerve/muscle symptoms.

    The only problem is that the more time I take benfotiamine, the more I get gut unconfort/fatigue/adrenal stress. I attribute this to the fact that thiamine is removing methylation blocks/ repairing vagal nerve. Also, in my methylation cycle, methionine is high while SAMe is low, which is an indication of low ATP, hence low thiamine. So taking thiamine increases methylation and this is what could be driving up my inflamation (and bile flow).

    Or because I am CBS heterozygous, and I could be diverting the transulfuration pathway towards sulfur.

    Your opinion?

    I beleive that b6 is a supplement that one should be careful with in the context of a cbs gene mutation. Not b1. In your position and withbtye number of people you see, I would love to know if you can make a study on cbs + people. That would be of great use to many people.

    1. Metronidazole has a structure that is the same as that of thiamine and substitutes for thiamine in body cells, thus inducing a novel form of thiamine deficiency. You are experiencing paradoxical symptomatic worsening and you must persist until paradox gives rise to symptomatic improvement. I don ‘t think that the heterozygous CBS matters

  5. This is very confusing. I had to look up the info on FRMPD4 and I see no connection at all with D-lactic acidosis, but it has been associated with autism. FRMPD4 codes for several proteins and is X linked, meaning that it is maternally inherited. Thiamin deficiency results in L-lactic acidosis and the only disease associated with D-lactic acid is “short bowel syndrome”, the result of surgical bowel resection. Thiamin will have no effect on D-lactic acid. The only connection that I can see is that the gene anomaly might result in misfolding of its associated proteins, but there is nothing to attach them to D-lactic acid production.

    1. I looked at my oldest son’s records again. I don’t know where I read D-lactic acidosis. The testing never mentioned D or L, so I will now assume that it must be the L type. His Lactate was elevated but Pyruvate was normal. Both sons and I were diagnosed to have FRMPD4. My youngest son was tested and diagnosed with duplications on 16p12.1 of 625 kilobases and on X chromosome Xq13.2 to Xq13.3 of approx. 1.03 megabases. My oldest son was only tested for FRMPD4. I was not able get this latter testing for my oldest son, due to insurance issues.
      I am sorry for jumping to conclusions regarding D-lactate acidosis. Those test results were done years ago, but he still experiences stomach problems, anxiety, motor issues and some other things that prompted me to respond to your website.
      I think that my frustration about being unable to fully explore medical options regarding his care caused assumptions that should not have been made.

    2. I was wondering why I thought that my son had D-lactate Acidosis. I was looking for Probiotic supplements specifically made for Autistic persons. What I found was a website (customprobiotics.com)with literature and a probiotic formula consisting of “D-Lactate free” microbes for people with Autism that have D-Lactate Acidosis issues.

  6. I was wondering what would be the best form at Thiamine for someone to take that is sensitive to too much sulphur build up in the body? I suffer from severe Dysautonomia, but I have a genetic mutation which disables me from breaking down sulfur in the body? Is there anyway around this so I can get the benefits of the Thiamine protocol?

    1. Thiamine has one sulfur atom as part of its chemical formula and is an essential item in the production of ATP, the energy currency that drives cellular function. There is no difference at all in the therapeutic action of different thiamine derivatives. Their ONLY additional benefit is that they can deliver thiamine to cells more easily than thiamine in its dietary form. Thiamine deficiency is probably the commonest, if not the only cause of dysautonomia. Beriberi is the prototype for dysautonomia. Since it is an absolutely essential component to life I cannot see how it’s one atom of sulfur can make a difference to you.

  7. Dr Lonsdale,
    Can I give lipothiamin to my 93 year old
    mother. She is loosing short term memory since about 2 years. She also has less energy.
    I take lipothiamin about for about 2 weeks and I have more energy and less anxiety.
    Thanks
    Zbigniew

    1. An interesting question!! The simplest answer is that I don’t know. However, a CBS mutation leads to a relative deficiency of glutathione and this is the biochemical lesion. One of the actions of thiamine is in the hexose monophosphate shunt that produces reducing equivalents, so at least thiamine might help to keep the existing glutathione reduced.

    1. Lipothiamine is an enteric coated tablet of TTFD, same as non-enteric coated Allithiamine, Both are trade names for thiamine tetrahydrofurfuryl disulfide (TTFD) and sold by Ecological Formulas in California, Reason for enteric coating is to avoid some loss of the intact molecule by hydrolysis from stomach acid.

    1. Cancer Chemother Pharmacol. 2014 Mar;73(3):585-94. doi: 10.1007/s00280-014-2386-z. Epub 2014 Jan 23.
      High-dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate.
      Hanberry BS1, Berger R, Zastre JA.

      The dichotomous effect of thiamine supplementation on cancer cell growth is characterized by growth stimulation at low doses and growth suppression at high doses

  8. Diagnosed 2012
    My regimen:
    The positives: no bradykinesia, I cut my food with a knife, no button difficulties, brush my teeth now w/o needing elect brush, more strength. Getting in and out of bed, turning over is easier. No more constipation. Parkinson’s progression stopped. Suppressed all motor and non-motor symptoms…
    Entering my 7th year post diagnosis and have not fallen, not once, to the surprise of my neuro. Was seeing neuro every 6th month, last visit he set app one year. He said if needed we could do some changes earlier. He said my condition can change in as little time as one week.
    New schedule, now I follow this regimen:
    3 x day C/L 50-200 ER : 8 am, 2 pm, 8 pm. Because it is ER, I take with or w/o food.
    2 x day (8 am 2g, and 2 pm 2g) Vitacost vitamin B1 (as thiamine HCL) 500mg, easy swallow capsules

    B1 Thiamine therapy reference / stop progression, suppress motor and non-motor symptoms:
    (Thiamine HCL is oral substitute to injecting B1) 2 x day (morning 2g and at lunch 2g)
    Doctor Costantini strategy that I find helpful “thiamine hcl stops the progression forever…”.
    Parky people say the first five years is your honeymoon stage with Parkinson’s. After that, progression more rapid.
    I have gone from slow motion to normal motor action since joining the growing number of PwP that have started B1 regimen/protocol. –
    Doctor Costantini – “Why is this? Because there is no medicine or drug that is able to affect all of the organs, whereas all of the organs function thanks to Thiamine. An important detail”, adds doctor Costantini, “the Thiamine therapy brings no collateral damage with time”.

  9. Dear Dr. Lonsdale,

    I’ve ordered some Alinamin A from Japan:
    “(In three tablets (maximum daily dose for 15 years or over)
    Ingredients/ Contents
    Fursultiamine (vitamin B1 derivative)/ 100mg
    (in fursultiamine hydrochloride equivalent,/ 109.16mg)
    Pyridoxine hydrochloride (vitamin B6)/ 20mg
    Cyanocobalamin (vitamin B12) / 60μg
    Riboflavin (vitamin B2)/ 12mg
    Calcium pantothenate/ 15mg”

    I also have some Arcalion (Sulbutiamin) at hand; I tend to get brain fog and lower mood from, especially when I do not add other B-vitamins. From my understand Sulbutiamine is the thiamin disulfide originally discovered by Williams, is this true? Citing from “Berri Beri and Thiamine (1964)”, page 154:
    “Thiamin disulfide: Absorption from the Intestinal tract: Limited; Enormous penetration into erythrocytes”
    So this is true for sulbutamine? It seems to enter my brain, judging by reaction… If used very high doses of Benfotiamine (up to 2 g/d) and never got the reaction described at the beginning of the paragraph.

    But now to my main question: Can I avoid the paradoxical start-up reaction by slowly titrating TTFD up (starting with one tablet containing 33 mg)? Because I need to keep on working while going through this…

    Thank you!

      1. Dear Dr. Lonsdale,

        I wonder if TTFD solution (from injectables) could be used in a nasal spray for more targeted brain support and smaller dosings. Do you think this would work?

          1. Hello again,

            I only could get allithiamine by ecological formulas. I take 50 mg in the morning on an empty stomach. In your experience, what total dosage and dosing interval make sense? I have CFS for over 20 or 25 years (started i childhood, but got worse in puberty) and damage to the atlantoaxial joint (not bone, but tendons)

              1. Dr. Lonsdale,

                using an app for rare diseases I’ve found this in my whole genome sequencing file:
                Gene: MTND5 Coordinate: MT:12706 No Risk T Risk C Your genetic makeup: C RISK DETECTED Possibly associated with Leigh Syndrome
                Literature: Taylor (2002), Thorburn (2003), Lebon (2003), GeneReviews (2014)

                Do you have advice what supplementation could be helpful with this?

                1. Leigh syndrome HAS been reported in relation to thiamine metabolism but the connection is far from clear. A case report for which I was a coauthor was published many years ago in which there was a brief response to TTFD but a great deal more research is needed to define Leigh syndrome.

  10. You seem to have a lot of cutting edge knowledge about Thiamine which ahs made me a fan, however you seem to equate TTFD to Lipothiamine. TTFD AFAIK is just AlliThiamine, a cousin to Sulbuthiamine: https://www.pureformulas.com/allithiamine-vitamin-b1-50-mg-60-capsules-by-ecological-formulas.html?CUSTOMTRACKING=CUSTOMTRACKING&CAWELAID=847733950&CAGPSPN=pla&CAAGID=61402356212&CATCI=pla-300685296414&CATARGETID=530005240008780909&cadevice=c&gclid=Cj0KCQiA-JXiBRCpARIsAGqF8wXgmk66yv0s4I6H88rAXHGaYrCRNfwp8oG1kuz266lictoDMuYkpasaAsikEALw_wcB

    As you clearly know, AlliThiamine and Sulbuthiamine are both thiamine derivatives, however Lipothiamine appears to be a combinational substance of AlliThiamine and Alpha Lipoic Acid (ALA): https://www.pureformulas.com/lipothiamine-60-tablets-by-ecological-formulas.html?CUSTOMTRACKING=CUSTOMTRACKING&CAWELAID=847734574&CAGPSPN=pla&CAAGID=61402356212&CATCI=pla-300685296414&CATARGETID=530005240008780909&cadevice=c&gclid=Cj0KCQiA-JXiBRCpARIsAGqF8wVhWzpghQC8G5YA0BHt6MiNZl4XV492HFtjAH6hI6ZN9vcUX9BSnL8aAmulEALw_wcB

    While ALA is good for some people, due to its chelation properties, it is not good for everyone (obviously see Dr. Cutler for the half life of ALA, its mercury chelation properties, etc).

    I am curious as to why you recommend Lipothiamine as opposed to pure Allithiamine, both produced by the same company, one with and one without ALA, when your entire argument is about Thiamine without any mention for ALA.

    As someone with Thimaine deficiency and mercury toxicity, I believe Lipothiamine would not be the right thing for me to take, although Allithimaine would theoretically be fine. That said, Dr. Cutler was not a fan TTFD and called it a toxic substance. I don’t necessarily subscribe to that idea but I am curious as to what you think about it.

    Thank you

    1. Let us be clear. Japanese investigators discovered allithiamine as a disulfide derivative in garlic. They did animal studies and found that it had a greater biological effect than the thiamine from which it was derived. They then synthesized a whole group of disulfides of which thiamine tetrhydrofurfuryl disulfide (TTFD) is the most modern. They also synthesized a group of acyl (non disulfide) derivatives. All are known as open ring forms of thiamine and their SOLE ACTION is to deliver thiamine to cells. The disulfides are reduced at the cell membrane enabling thiamine to pass through the lipid barrier whereas the acyl derivatives (e.g.benfotiamine} require an enzyme to break off the prosthetic group and do not have the same advantage of absorption.
      ALLITHIAMINE and LIPOTHIAMINE are trade names for TTFD. Sulbutiamine is another disulfide.
      Why does Lipothiamine contain a very small dose of lipoic acid????
      I asked the CEO of Ecological Formulas to create a TTFD with enteric coating to ensure that TTFD would pass through the stomach acid to get to the jejunum where thiamine is absorbed. He already had a lipoic acid pill and simply added TTFD to it, knowing that the tiny dose of lipoic acid would not add or subtract from the biological effect of TTFD.

      1. Hello Mr.Lonsdale

        I have one question regarding the intake of Allithiamine.
        Does it make sense to take Allithiamine on an empty stomach or is it better to take it with food?
        Im wondering if the stomach acid destroys the Allithiamine structure and theresfore does make it not working anymore!? Thank you very much

        Regards

        Steffen

        1. Stomach acid does have some destructive action. That is why Lipothiamine is enteric coated. Both of them are TTFD

      2. Thanks for asking Ecological Formulas to make both the Allithiamine and Lipothiamine. I first thought I was going to have a hard time finding it. I just ordered the Lipothiamine.
        I’m ordering this to see if will help my adult autistic, developmentally delayed son and myself. When he was a young boy, his blood tests indicated something off regarding D-Lactate Acidosis levels. His doctors never did anything about it. He’s into gymnastics and ice hockey, but always complains of being tired. He was recently diagnosed with FRMPD4. He also has neutropenia at times. There’s no formal name for this newly discovered genetic anomaly. It’s supposed to lead to Autistic tendencies. The thing is, I have another younger son with the same genetic marker, yet he isn’t Autistic and has unexplained physical anomalies. Very confusing.
        Regarding myself, I was quite athletic as a child and used to run track. I eventually stopped running, because I would randomly pass out after running sprint races. It got to be embarrassing by my teens, so I quit. I was physically active as an adult, but still randomly passed out after physical activity(ie. Bike riding, weight training, jogging…)
        I bought Benfotiamine for my oldest son, but it had no discernible effect. After reading your articles about TTFD, I wanted to try again. Ideally, I would have my oldest son tested again to see if he still has problems with D-Lactate Acidosis. With his insurance(Medicaid) and his present doctor, I don’t see it happening without spending cash that I don’t have.

  11. Dr. Lonsdale, you state that Benfotiamine, does not get into the brain, whereas TTFD enables absorption of thiamine into the brain. I understand we are to take magnesium, a good B-complex along with Thiamine.
    Is there a brand that contains TTFD that you would recommend? My son’s naturopath recommended Benfotiamine, but I want to ensure that I’m giving my 13yo son the right thiamine. My son has hypersensitive hearing (misophonia) and I started giving him 150 mg of benfotiamine and I have noticed a difference in him in just 3 days. Thank you for your guidance.

    1. Both Benfotiamine (BF) and Lipothiamine (LP) are what is known as open ring forms of thiamine. Their job is to deliver thiamine into the cell and is their sole function. Animal studies done some years ago showed that BF did not cross the blood brain barrier, whereas LP did. That is the only science available concerning this. There is a lot more research about these two derivatives, well beyond the scope of writing anything here, but my studies of this research have settled for LP as the best derivative. That does not mean that BF is inferior to LP, it just has a different way of delivering thiamine to the cells that need it. If you have found that BF works, that is fine.

  12. Dr. Lonsdale,

    Oh how I would give my entire savings to be able to work with you! Can you offer any advice on someone in practice who is knowledgeable in your wisdom?! I have eoe. My kids have eoe, Mast Cell Activation, and a ton of ige allergies. My mom has rheumatoid arthritis, as does my grandma. Our family has a lot of Alcoholics and sugar addicts. My boys are popping up with a lot of elevated levels such as tnf-a, eosinophils, IL-13……. so much of my health problems stem back to this dang eoe! I desperately want to try the thiamine therapy on them, even possibly order the IVs from Japan! However, every time I bring it up to a doctor or naturopath, they treat me like I’m crazy. his blood test revealed a minor deficiency and they keep telling me to just give him a B complex. Is there anyone who could help me with this?! Please, I am desperate for my babies! I have read a lot of your work and try to understand as much as I could. When I asked for the test you mentioned, my doctor had no clue what I was talking about. I am giving them one capsule of the liposomal thiamine a day currently, however I have no idea what I should be giving them to be therapeutic! I’m really wondering if this could help our health and if there’s any way I can find someone to help us?! Thank you so much for your wisdom, dedication, and time! Shawna Robinson

  13. Dr Derrick, It seems I have issues taking Benfotiamine as it contains a lot of Sulfur. I do have an overgrowth of Sulphate Reducing bacteria SIBO which converts sulfur to the toxic Hydrogen Sulphide. What options do I have to increase my B1 levels? Is there a away i can consult you for my anxiety issues. Thanks, Racerbiker

    1. There are several points at issue here. 1. I am retired and do not consult. 2. The only sulfur in Benfotiamin is in thiamin. 3. SIBO is fashionable at the moment and makes little sense to me. 4. What makes you believe that you have low vitamin B1 levels? State your clinical symptoms and a little bit of your medical history.

      1. Thanks Dr Lonsdale.
        I have been advised to take Benfotamine for my back pain due to muscle inflammation and weakness. I do have sulfur intolerance issues as I get a stomach upset on eating foods high in sulfur and thiols. Have a leaky gut, gut inflammation, intolerant to many foods in lectins, sulfation issues leading to poor detoxification of catecholamines, phenols and anxiety issues due to all of this. I heard Benfotamine also helps in reducing brain inflammation and hence wanted to try it but they gave me anxiety. Please help. Thanks

          1. Thanks Dr Lonsdale, My symptoms are anxiety, panic attacks, brain fog with some foods, hair loss, chronic, shoulder tics, fear of impending doom, fatigue, food sensitivities to anything high sulfur/estrogen/phenols.

            1. These are the symptoms of defective energy metabolism in the brain. They might respond to supplementary thiamine and magnesium. If the symptoms become worse, you may be experiencing a paradoxical effect which is temporary, although its lasting effect is unpredictable

              1. Thanks Dr Lonsdale. I do react to Sulfur/Sulfate and high protein based foods in the form of Anxiety and fatigue. Does Benfotamine contain sulfur and will it cause me Anxiety if I take it?

  14. Dr Lonsdale I’m curious to get your take on Fibromyalgia, is it just beriberi with a new name? Also, after our microbiome discussion and the idea that bacteria in the gut are using our thiamine too….is IV thiamine supplementation the way to go? By doing so, one could bypass any small intestine absorption issues and possible pathogens that reside there? Get thiamine to the brain more effectively, where it is needed to stop this vicious cycle from happening. If so, what type, dosage and frequency would you sugggest? I doubt one can get Lipothiamine in IV form?

    Thanks as always for your persistence in wanting to help all be healthy

    1. This post illustrates the difficulty that I have in getting people to understand that thiamin is not a drug, but when it is being used in megadoses it becomes a drug, a classic oxymoron. It also illustrates that naming a particular disease as though it were a unique phenomenon on its own is misleading. Chronic fatigue syndrome represents a set of symptoms that are entirely due to disease resulting from thiamin deficiency, whereas the cause for chronic fatigue syndrome has long been sought as ANOTHER disease with a separate cause. If you see chronic fatigue syndrome and beriberi deficiency of cellular energy from mitochondrial dysfunction. Beriberi is regarded as THE as variable examples of cellular energy deficiency, you can immediately begin to understand that the present disease model is a catastrophe. If you see each constellation of symptoms as a separate expression of disease and give it a name without knowing the underlying cause you wind up with a monstrous collection of disease entities and that is exactly what we have. The fundamental need is for a physician to see the constellation of symptoms as a variable expression of a combination of factors that include the genetic background of a given individual, the life stresses being experienced and the quality of nutrition.Let me give you an example. An observer by the name of Parkinson recognized a constellation of symptoms that is now called Parkinson’s disease. There is already ample evidence that it is an expression of a combination of genetic risk, life stresses including aging and malnutrition. It is true that one or other of these three elements may be the dominant one in an individual case, but the usual expression includes all three. That is why there is now considered to be a genetic expression of Alzheimer’s disease as well as an acquired cause. There is also evidence that our mitochondria can be damaged during life although the current view is that mitochondrial disease is genetic in origin,period.Lastly, thiamin should not be given on its own for anything. It should always be used as a senior team member

      1. I get the concept of this being a root cause/factor of many so called seperate diseases/syndromes….but out here in today’s America people are being told they have fibro, sibo, or x, y, and z disease…not yesterdays beriberi. We are trying to make connections with what you are saying and what we have been told we have. So it’s a question of who to believe. I’ve mentioned modern high calorie thiamine deficiency as a root cause to nervous system disfunction to several of my doc’s, of various disciplines(including functional)and they look at me like I’m crazy. When I say there is no lab currently doing the right thiamine test to prove this, I totally lose them. I like the theory but without the proper testing to prove it, it’s still going to be called sibo or fibro or x,y,z., p, d, q disease.Case studies help, but are particular to that far away patient….each person needs their own test result , right in front of their doctor, to truly know.

        I also get that Thiamine supplementation needs it’s cofactors of magnesium, other B’s, and a multi to get results. Still thiamine is the key and the method in which one administers it, how much, and how often is also a key factor. So do you recommend IV therapy and the Meyers Cocktail as the way to best do this? Is the amount of thiamine in that enough? Or is there a Lonsdale Cocktail you can recommend one tries?Can you get Lipothiamine in IV form from Cardiovascular Research Ltd?

        One more…EpicGenetics(FM/a test) want to try and treat Fibro with an old school, cheap, safe(?) TB vaccine BcG….its waiting for FDA trial approval now. What says you about this idea?

        Thanks

        1. Oh how I sympathize! I have been in this situation for nearly 40 years. The chief of pediatrics at Cleveland Clinic was my friend until I started working with vitamin therapy and he then turned against me with all the rest of my colleagues. Later, long after he had retired, I visited him in Florida and he admitted that I was 20 years ahead of my time. Do you think that I don’t recognize this, the proverbial sore thumb? The only thing that I can do is to write about it and support it with all the evidence that I can muster. I do not expect recognition although I might have a voice after I am long gone and that is why Dr. Marrs and I wrote our book “Thiamine Deficiency Disease, Dysautonomia and High Calorie Malnutrition”, available at Amazon books. If it is not read or discarded as BS, the message is lost. Let me now try to answer your questions.
          Yesterday’s beriberi
          Obviously this is a current concept. The entire orthodox medical fraternity strongly believes that beriberi is only of historical interest. Please remember that beriberi is derived from the Chinese language and its translation is “I can’t, I can’t”. It is meaningless unless you understand what the ancient Chinese were seeing as the behavior of huge numbers of people suffering from a nutritional disease for which they had absolutely no idea of cause. Unfortunately modern physicians are wrong and I have proved it to the hilt many times. I have tried writing about it in the medical literature, but it still comes down to the way that the reader has been programmed to believe ( note the word believe) the reality of health and disease. A physician may read an abstract and say to himself “this is absurd” and throw the paper away. It takes years and years for a new concept in medicine to become acceptable and only if it is eventually proved by the evidence.
          Who to believe?
          Exactly! Belief comes eventually from proof and that takes time. I am hopefully building up the evidence before I pass on.
          A test result is essential
          Exactly! One of the anomalies that I have discovered is that current laboratory tests available are usually misleading. The blood level of vitamin B1 is usually normal in moderate (and I mean moderate) deficiency. The erythrocyte transketolase is usually normal as well. The enzyme has to be tested for thiamin deficiency by adding thiamin to the test tube reaction. If the enzyme activity (TKA) accelerates, it is simply registering the fact that the addition of thiamin is necessary for its full activity and is called the thiamin pyrophosphate effect (TPPE). Hundreds if not thousands of times I have seen patients where the TKA is within the normal range but the TPPE is grossly abnormal. Furthermore, after thiamine therapy the TKA increases a little bit but the TPPE decreases, usually to zero, meaning that there is no further acceleration of enzyme activity. Thiamin is required INSIDE the cells and not just floating in the blood. TKA and TPPE are testing the BIOLOGICAL function of the enzyme, not just its presence.
          Intravenous vitamins
          Please understand that we are not talking about vitamin deficiency simply being replaced. We are talking about disease as a manifestation of energy deficiency in our cells, particularly in the brain. Hence, the symptoms vary according to the distribution of the energy deficiency. Vitamin B1 and all its colleagues are being used as “drugs” in large doses in an effort to enable the cells to build up their energy profile. We have recognized that giving the vitamins by mouth may not reach the concentration required in the cell. By using all the water soluble vitamins intravenously, we are providing a large concentration of the “drugs”.
          Intravenous Lipothiamine
          Yes, it is available. It is made by Takeda Biochemicals in Osaka Japan. It is not recognized in the United States by the FDA but I had an independent investigator license for many years and have used it on many patients, as well as writing about it in the medical literature (again that has to be read). It has incredible value as a therapeutic agent because it addresses the core issue of disease, defined as “The Diseases of Adaptation” (Selye H, 1976).
          BCG for Fibro
          I do not know what “Fibro” stands for. I have to presume that it is being regarded as a disease of “failed immunity” and the BCG is presumably being used to stimulate immunity. If I am right it will not work!
          Lastly, what Dr. Marrs and I are essentially saying is that disease is a result of energy deficiency affecting cellular function in the brain. We regard thiamin as an important therapeutic agent because of its place in energy metabolism. There is a tremendous amount of evidence in the medical literature that thiamin deficiency can be precipitated in stressful situations such as cancer, following surgery and in chronic degenerative diseases. Ask your “Doubting Thomas’s” to research the literature.It seems incongruous that we have been able to report two children with febrile lymphadenopathy (sore throat, swollen neck glands and fever) and another child with chronic asthma who responded to megadoses of thiamin. It is this kind of experience which has suggested to us that the present medical model is a catastrophe

          Selye H. The stress concept. Can Med Assoc J 1976, 115(8):718

          1. The Healthcare model in this country is a castrophe. 5 minute consults with quick, dirty, and repetitive/lucrative big pharmachemical prescriptions…is capitalism at its worst. Prescribing something that numbs symptoms but doesnt cure, that most likely will give you something else, that you need another med for, is healthcare desguised as greed. I just think you can’t have true healthcare that is capitalistic in nature. Greed can have no part in this. The goal should be health not wealth. But there is less wealth if everybody is healthy, so you have what we have today. Now you think a deal could be struck in one of the wealthiest countries in the world. Where the best capitalistic system supports the best socialistic healthcare system. Because if you don’t have your health, what point is wealth? But perhaps I’m missing something here, maybe wealth is buying real healthcare today? When a billionaire can have fearless unprotected sex with a porn star and a playmate in the same weekend (every weekend) and still be well enough to become president… leads me to believe there is more going in healthcare than what meets my equal treatment for all eye. Enough of the stinking politics…on to the good stuff- Science!

            Takeda Biochemicals is now Takeda Pharmaceuticals….they have Japanese division and a US division. The US site only mentions pharmcueticals they offer, where as the Japanese site list supplements too….interesting. There they have a product called Alinamin which is b1 from Fursultiamine(?) and other B’s, plus vit E. Says it treats eyestrain, stiff shoulder of 50 years of age(love the Japanese), pains of the waste and lower back, neuralgia, and numbness of extremities….hmm sounds like dry beriberi and say…. fibromyalgia!…. all symptoms I have.

            The Personality and The Chasse….but within that Chasse lies what fuels that Personality …the gut. Wouldn’t you say ? Hypocreatties was and is still right. Really a symbiotic relationship between the two working to control everything. If there are bad weeds(bacteria’s, yeasts, virus’) in either and in the wrong places trouble arises. We really need GastroNeurologists. There is a functional doctor named Allison Siebecker of the Natural University of Natural Medicine that treats SIBO naturally. She may be one that would by into your thiamine theory and have the lab resources to properly test it perhaps? I sent an email about your book/theory to Dr Mark Pimentel’s( dr sibo) lab at Cedars-Sinai and never heard back. We need somebody to do the proper testing!…..not tied to big pharmachemical !!

            From EpicGenetics ( ones with FM/a fibromyalgia test and possible BCG treatment)…”Fibromyalgia is a misnomer. The disease process is neither a fibrous or a muscular disorder. The disease should be called the immune dysfunction or suppression disorder. Critical white blood cells within the body’s immune system which are peripheral blood mononuclear cells lack the capacity to produce adequate and normal quantities of vital the proteins Chennokines and Cytokines.”
            What says Dr Lonsdale about this…any experience giving BCG, it’s no longer given in US for some reason, yet schools quarantine kids suspected of TB.

            Odds and ends…I have two friends one with MS(was an alcoholic) and one with dystonia(is an antibiholic). Has thiamine therapy shown to reduce MS plaques or treat dystonia in any way? Using oral or IV therapy? On a personal note I was told to stop supplementing with magnesium because my levels were too high on an interacelluar blood test. You say one has to take magnesium when taking thiamine, in my case would I not take it alongside the lippothiamine ?

            The End…Happy Easter Dr Lonsdale and thanks for your continued guidance & knowledge

  15. Very good way to refute the accusation. I did a little detective work. This same “reviewer” left a similar review for Benfotiamine product on iHerb in 2010. I would guess from the number of reviews this person made around that time, that there could have been an adverse reaction to the multiple products potentially being used and blamed it on the Allithiamine. I saw this review when I ordered my Allithiamine months ago, so your explanation was of great interest to me.

    The note about TTFD helping to protect against carbon tetrachloride toxicity in the liver could be very helpful to my illness, as a secondary benefit! Thank you, again!

Leave a Reply

Your email address will not be published. Required fields are marked *

two + twenty =

This site uses Akismet to reduce spam. Learn how your comment data is processed.