About TTFD: A Thiamine Derivative

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TTFD thiamine
I recently received notification concerning a “review” posted on HerbCustomer, a commercial website that has been active since February 26, 2010. This so-called “review” was posted on January 16, 2018 by iHerbCustomer entitled “Dangerous allithiamine derivative with no thiamine activity”. The email was posted as well. This person made a potentially libelous statement by referring to me as lying about this thiamine derivative. Its commercial name is Lipothiamine. Its chemical name is thiamine tetrahydrofurfuryl disulfide (TTFD) and this post is to refute the accusations that are made public by this individual.

History of Thiamine Research

Thiamine is the chemical name for vitamin B1 and its deficiency in the diet has long been known as the cause of beriberi. This disease has been known for thousands of years but its underlying cause was only discovered in the closing years of the 19th century. Since beriberi was commonest in the rice consuming cultures, it is not surprising that the major research came from Japan. In the middle of the last century a group of university-based scientists was convened and they wrote a book (Review of the Japanese Literature on Beriberi and Thiamine). This was translated into English, ostensibly because these scientists wished to let people in the West know and understand the pernicious nature of disease resulting from thiamine deficiency. I was fortunate enough to receive a copy of this book from one of the scientists involved. The information in this post is derived from it. Because they were scientists and were well aware of the clinical effects of beriberi, their studies were very extensive. They knew that thiamine existed in garlic and much of their experimentation focused on studies of the garlic bulb. They discovered that there was a natural mechanism in garlic that created a derivative of thiamine and called it allithiamine. Note that this is a naturally occurring substance and the term should be entirely restricted to it.

On a number of occasions I have seen thiamine derivatives being called “The alithiamines” and one commercial product is called Allithiamine with a capital a. The name was given to this naturally occurring product because garlic is a member of the allium species of plants. It can be found in other members of the allium species. Because the Japanese scientists already knew a great deal about the clinical expressions caused by thiamine deficiency, they originally thought that this new derivative might have lost its vitamin dependent activity. They went on to test it in animal studies and found that it had a much greater biologic effect than the original thiamine from which it was derived. They found that it was extremely important that allithiamine was a thiamine disulfide derivative (disulfides are important in human physiology) and they synthesized many different types of thiamine disulfide as well as many non-disulfide derivatives, carefully testing each one for their biologic activity.

What is TTFD?

Without going into the biochemical details, what we now know is that thiamine tetrahydrofurfuryl disulfide (TTFD, Lipothiamine) is, for a number of reasons, the best of the bunch of synthetically produced derivatives and has exciting possibilities in therapy. For example, it has been shown from animal studies that Benfotiamine, a non-disulfide derivative, does not get into the brain whereas TTFD enables absorption of thiamine into the brain where it stimulates energy synthesis. When we take in thiamine, occurring only in our naturally formed food, it is biologically inert. It has to be “activated” within the body that possesses genetically determined mechanisms for its absorption and activation. To cut a technically difficult explanation, let me state that TTFD bypasses this process. It enables thiamine to split away from its disulfide attachment and enter the cells where its activity is required. The concentration achieved in the target cells is much greater than that achieved by the administration of the thiamine from which it was derived.

The Japanese scientists studied the effect of cyanide in mice and found that thiamine propyl disulfide (TPD), a forerunner of TTFD, gave significant protection from the lethal effect of this poison, an incredible discovery that alone should raise eyebrows. They studied this effect and were able to show its mechanism. They also found that it would protect animals from the effect of carbon tetrachloride, a poison that affects the liver. It is using its vitamin actions in a therapeutic manner.

Being myself a consultant pediatrician in a prestigious medical institution, I was able to obtain an independent investigator license (IND) from the Federal Drug Administration, and obtained TTFD from Takeda Chemical Industries in Osaka, Japan, the makers of this product. TTFD is a prescription item in Japan, sold under the commercial name of Alinamin. I have read several publications, showing that it reverses fatigue in both animal and human studies. I was able to study the value of this incredible substance in literally hundreds, if not thousands of patients. Far from being toxic, as this person claims, I never saw a single item that suggested toxicity. Its therapeutic potential is largely untapped in America. This is because the current medical model does not recognize that defective energy metabolism, genetic errors and the nature of stress are the interrelated components whose variable effects in combination are the cause of disease. Do not mistake the use of the word stress, a word that is so commonly used inappropriately. An infection and any form of physical or mental trauma represent a form of stress. It is the ability or the inability to meet the required energy demand to resist that stress that matters in the preservation of health.

Clinical Benefits of TTFD

It is important to understand that the beneficial activity of TTFD is exactly the same as the thiamine from which it is derived. It is the mechanism of its introduction to cells, particularly those in the brain, that enable it to have such an effect on energy metabolism. Because of its strategic position in the cell, thiamine is of vast importance in oxidative metabolism in the complex mechanisms of energy production. There are at least two methods by which thiamine deficiency can be induced. The commonest one is an excess of sugar and fat that overwhelms the capacity of thiamine to conduct the mechanisms involved in energy synthesis. The discovery that thiamine has a part to play in fat metabolism is quite recent. The other one is because of genetic errors involving its biochemical action. However, we now know from a relatively new science called epigenetics that some mistakes in DNA can be overcome by the use of an appropriate nutritional substance like thiamine. The completely non-toxic use of TTFD depends merely on its ability to introduce thiamine into the cells of the body that require its magic. Under these circumstances, the big doses of thiamine are acting like a pharmaceutical by stimulating the missing action. We are not dealing with simple vitamin replacement. This should represent a new era in medicine when nutrient biochemistry takes its place in patient care.

Conclusion

The person that wrote this criticism fails to understand that TTFD and other thiamine derivatives represent a new basic principle of therapy. It recognizes that healing is a function of the body, not the activity of a so-called “healer”. All it requires is the foundation substances needed for repair and sufficient energy to use them. It demands a dramatic change in thinking about health and disease. If you understand the principles involved, it forces the conclusion that the word “cure” is a pipe dream. The only form of pharmaceutical drug that matters is one that safely kills an attacking microbe. Almost all the rest of them merely relieve symptoms and have no effect on the ultimate outcome.

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22 Comments

  1. You seem to have a lot of cutting edge knowledge about Thiamine which ahs made me a fan, however you seem to equate TTFD to Lipothiamine. TTFD AFAIK is just AlliThiamine, a cousin to Sulbuthiamine: https://www.pureformulas.com/allithiamine-vitamin-b1-50-mg-60-capsules-by-ecological-formulas.html?CUSTOMTRACKING=CUSTOMTRACKING&CAWELAID=847733950&CAGPSPN=pla&CAAGID=61402356212&CATCI=pla-300685296414&CATARGETID=530005240008780909&cadevice=c&gclid=Cj0KCQiA-JXiBRCpARIsAGqF8wXgmk66yv0s4I6H88rAXHGaYrCRNfwp8oG1kuz266lictoDMuYkpasaAsikEALw_wcB

    As you clearly know, AlliThiamine and Sulbuthiamine are both thiamine derivatives, however Lipothiamine appears to be a combinational substance of AlliThiamine and Alpha Lipoic Acid (ALA): https://www.pureformulas.com/lipothiamine-60-tablets-by-ecological-formulas.html?CUSTOMTRACKING=CUSTOMTRACKING&CAWELAID=847734574&CAGPSPN=pla&CAAGID=61402356212&CATCI=pla-300685296414&CATARGETID=530005240008780909&cadevice=c&gclid=Cj0KCQiA-JXiBRCpARIsAGqF8wVhWzpghQC8G5YA0BHt6MiNZl4XV492HFtjAH6hI6ZN9vcUX9BSnL8aAmulEALw_wcB

    While ALA is good for some people, due to its chelation properties, it is not good for everyone (obviously see Dr. Cutler for the half life of ALA, its mercury chelation properties, etc).

    I am curious as to why you recommend Lipothiamine as opposed to pure Allithiamine, both produced by the same company, one with and one without ALA, when your entire argument is about Thiamine without any mention for ALA.

    As someone with Thimaine deficiency and mercury toxicity, I believe Lipothiamine would not be the right thing for me to take, although Allithimaine would theoretically be fine. That said, Dr. Cutler was not a fan TTFD and called it a toxic substance. I don’t necessarily subscribe to that idea but I am curious as to what you think about it.

    Thank you

    1. Let us be clear. Japanese investigators discovered allithiamine as a disulfide derivative in garlic. They did animal studies and found that it had a greater biological effect than the thiamine from which it was derived. They then synthesized a whole group of disulfides of which thiamine tetrhydrofurfuryl disulfide (TTFD) is the most modern. They also synthesized a group of acyl (non disulfide) derivatives. All are known as open ring forms of thiamine and their SOLE ACTION is to deliver thiamine to cells. The disulfides are reduced at the cell membrane enabling thiamine to pass through the lipid barrier whereas the acyl derivatives (e.g.benfotiamine} require an enzyme to break off the prosthetic group and do not have the same advantage of absorption.
      ALLITHIAMINE and LIPOTHIAMINE are trade names for TTFD. Sulbutiamine is another disulfide.
      Why does Lipothiamine contain a very small dose of lipoic acid????
      I asked the CEO of Ecological Formulas to create a TTFD with enteric coating to ensure that TTFD would pass through the stomach acid to get to the jejunum where thiamine is absorbed. He already had a lipoic acid pill and simply added TTFD to it, knowing that the tiny dose of lipoic acid would not add or subtract from the biological effect of TTFD.

  2. Dr. Lonsdale, you state that Benfotiamine, does not get into the brain, whereas TTFD enables absorption of thiamine into the brain. I understand we are to take magnesium, a good B-complex along with Thiamine.
    Is there a brand that contains TTFD that you would recommend? My son’s naturopath recommended Benfotiamine, but I want to ensure that I’m giving my 13yo son the right thiamine. My son has hypersensitive hearing (misophonia) and I started giving him 150 mg of benfotiamine and I have noticed a difference in him in just 3 days. Thank you for your guidance.

    1. Both Benfotiamine (BF) and Lipothiamine (LP) are what is known as open ring forms of thiamine. Their job is to deliver thiamine into the cell and is their sole function. Animal studies done some years ago showed that BF did not cross the blood brain barrier, whereas LP did. That is the only science available concerning this. There is a lot more research about these two derivatives, well beyond the scope of writing anything here, but my studies of this research have settled for LP as the best derivative. That does not mean that BF is inferior to LP, it just has a different way of delivering thiamine to the cells that need it. If you have found that BF works, that is fine.

  3. Dr. Lonsdale,

    Oh how I would give my entire savings to be able to work with you! Can you offer any advice on someone in practice who is knowledgeable in your wisdom?! I have eoe. My kids have eoe, Mast Cell Activation, and a ton of ige allergies. My mom has rheumatoid arthritis, as does my grandma. Our family has a lot of Alcoholics and sugar addicts. My boys are popping up with a lot of elevated levels such as tnf-a, eosinophils, IL-13……. so much of my health problems stem back to this dang eoe! I desperately want to try the thiamine therapy on them, even possibly order the IVs from Japan! However, every time I bring it up to a doctor or naturopath, they treat me like I’m crazy. his blood test revealed a minor deficiency and they keep telling me to just give him a B complex. Is there anyone who could help me with this?! Please, I am desperate for my babies! I have read a lot of your work and try to understand as much as I could. When I asked for the test you mentioned, my doctor had no clue what I was talking about. I am giving them one capsule of the liposomal thiamine a day currently, however I have no idea what I should be giving them to be therapeutic! I’m really wondering if this could help our health and if there’s any way I can find someone to help us?! Thank you so much for your wisdom, dedication, and time! Shawna Robinson

  4. Dr Derrick, It seems I have issues taking Benfotiamine as it contains a lot of Sulfur. I do have an overgrowth of Sulphate Reducing bacteria SIBO which converts sulfur to the toxic Hydrogen Sulphide. What options do I have to increase my B1 levels? Is there a away i can consult you for my anxiety issues. Thanks, Racerbiker

    1. There are several points at issue here. 1. I am retired and do not consult. 2. The only sulfur in Benfotiamin is in thiamin. 3. SIBO is fashionable at the moment and makes little sense to me. 4. What makes you believe that you have low vitamin B1 levels? State your clinical symptoms and a little bit of your medical history.

      1. Thanks Dr Lonsdale.
        I have been advised to take Benfotamine for my back pain due to muscle inflammation and weakness. I do have sulfur intolerance issues as I get a stomach upset on eating foods high in sulfur and thiols. Have a leaky gut, gut inflammation, intolerant to many foods in lectins, sulfation issues leading to poor detoxification of catecholamines, phenols and anxiety issues due to all of this. I heard Benfotamine also helps in reducing brain inflammation and hence wanted to try it but they gave me anxiety. Please help. Thanks

          1. Thanks Dr Lonsdale, My symptoms are anxiety, panic attacks, brain fog with some foods, hair loss, chronic, shoulder tics, fear of impending doom, fatigue, food sensitivities to anything high sulfur/estrogen/phenols.

            1. These are the symptoms of defective energy metabolism in the brain. They might respond to supplementary thiamine and magnesium. If the symptoms become worse, you may be experiencing a paradoxical effect which is temporary, although its lasting effect is unpredictable

              1. Thanks Dr Lonsdale. I do react to Sulfur/Sulfate and high protein based foods in the form of Anxiety and fatigue. Does Benfotamine contain sulfur and will it cause me Anxiety if I take it?

  5. Dr Lonsdale I’m curious to get your take on Fibromyalgia, is it just beriberi with a new name? Also, after our microbiome discussion and the idea that bacteria in the gut are using our thiamine too….is IV thiamine supplementation the way to go? By doing so, one could bypass any small intestine absorption issues and possible pathogens that reside there? Get thiamine to the brain more effectively, where it is needed to stop this vicious cycle from happening. If so, what type, dosage and frequency would you sugggest? I doubt one can get Lipothiamine in IV form?

    Thanks as always for your persistence in wanting to help all be healthy

    1. This post illustrates the difficulty that I have in getting people to understand that thiamin is not a drug, but when it is being used in megadoses it becomes a drug, a classic oxymoron. It also illustrates that naming a particular disease as though it were a unique phenomenon on its own is misleading. Chronic fatigue syndrome represents a set of symptoms that are entirely due to disease resulting from thiamin deficiency, whereas the cause for chronic fatigue syndrome has long been sought as ANOTHER disease with a separate cause. If you see chronic fatigue syndrome and beriberi deficiency of cellular energy from mitochondrial dysfunction. Beriberi is regarded as THE as variable examples of cellular energy deficiency, you can immediately begin to understand that the present disease model is a catastrophe. If you see each constellation of symptoms as a separate expression of disease and give it a name without knowing the underlying cause you wind up with a monstrous collection of disease entities and that is exactly what we have. The fundamental need is for a physician to see the constellation of symptoms as a variable expression of a combination of factors that include the genetic background of a given individual, the life stresses being experienced and the quality of nutrition.Let me give you an example. An observer by the name of Parkinson recognized a constellation of symptoms that is now called Parkinson’s disease. There is already ample evidence that it is an expression of a combination of genetic risk, life stresses including aging and malnutrition. It is true that one or other of these three elements may be the dominant one in an individual case, but the usual expression includes all three. That is why there is now considered to be a genetic expression of Alzheimer’s disease as well as an acquired cause. There is also evidence that our mitochondria can be damaged during life although the current view is that mitochondrial disease is genetic in origin,period.Lastly, thiamin should not be given on its own for anything. It should always be used as a senior team member

      1. I get the concept of this being a root cause/factor of many so called seperate diseases/syndromes….but out here in today’s America people are being told they have fibro, sibo, or x, y, and z disease…not yesterdays beriberi. We are trying to make connections with what you are saying and what we have been told we have. So it’s a question of who to believe. I’ve mentioned modern high calorie thiamine deficiency as a root cause to nervous system disfunction to several of my doc’s, of various disciplines(including functional)and they look at me like I’m crazy. When I say there is no lab currently doing the right thiamine test to prove this, I totally lose them. I like the theory but without the proper testing to prove it, it’s still going to be called sibo or fibro or x,y,z., p, d, q disease.Case studies help, but are particular to that far away patient….each person needs their own test result , right in front of their doctor, to truly know.

        I also get that Thiamine supplementation needs it’s cofactors of magnesium, other B’s, and a multi to get results. Still thiamine is the key and the method in which one administers it, how much, and how often is also a key factor. So do you recommend IV therapy and the Meyers Cocktail as the way to best do this? Is the amount of thiamine in that enough? Or is there a Lonsdale Cocktail you can recommend one tries?Can you get Lipothiamine in IV form from Cardiovascular Research Ltd?

        One more…EpicGenetics(FM/a test) want to try and treat Fibro with an old school, cheap, safe(?) TB vaccine BcG….its waiting for FDA trial approval now. What says you about this idea?

        Thanks

        1. Oh how I sympathize! I have been in this situation for nearly 40 years. The chief of pediatrics at Cleveland Clinic was my friend until I started working with vitamin therapy and he then turned against me with all the rest of my colleagues. Later, long after he had retired, I visited him in Florida and he admitted that I was 20 years ahead of my time. Do you think that I don’t recognize this, the proverbial sore thumb? The only thing that I can do is to write about it and support it with all the evidence that I can muster. I do not expect recognition although I might have a voice after I am long gone and that is why Dr. Marrs and I wrote our book “Thiamine Deficiency Disease, Dysautonomia and High Calorie Malnutrition”, available at Amazon books. If it is not read or discarded as BS, the message is lost. Let me now try to answer your questions.
          Yesterday’s beriberi
          Obviously this is a current concept. The entire orthodox medical fraternity strongly believes that beriberi is only of historical interest. Please remember that beriberi is derived from the Chinese language and its translation is “I can’t, I can’t”. It is meaningless unless you understand what the ancient Chinese were seeing as the behavior of huge numbers of people suffering from a nutritional disease for which they had absolutely no idea of cause. Unfortunately modern physicians are wrong and I have proved it to the hilt many times. I have tried writing about it in the medical literature, but it still comes down to the way that the reader has been programmed to believe ( note the word believe) the reality of health and disease. A physician may read an abstract and say to himself “this is absurd” and throw the paper away. It takes years and years for a new concept in medicine to become acceptable and only if it is eventually proved by the evidence.
          Who to believe?
          Exactly! Belief comes eventually from proof and that takes time. I am hopefully building up the evidence before I pass on.
          A test result is essential
          Exactly! One of the anomalies that I have discovered is that current laboratory tests available are usually misleading. The blood level of vitamin B1 is usually normal in moderate (and I mean moderate) deficiency. The erythrocyte transketolase is usually normal as well. The enzyme has to be tested for thiamin deficiency by adding thiamin to the test tube reaction. If the enzyme activity (TKA) accelerates, it is simply registering the fact that the addition of thiamin is necessary for its full activity and is called the thiamin pyrophosphate effect (TPPE). Hundreds if not thousands of times I have seen patients where the TKA is within the normal range but the TPPE is grossly abnormal. Furthermore, after thiamine therapy the TKA increases a little bit but the TPPE decreases, usually to zero, meaning that there is no further acceleration of enzyme activity. Thiamin is required INSIDE the cells and not just floating in the blood. TKA and TPPE are testing the BIOLOGICAL function of the enzyme, not just its presence.
          Intravenous vitamins
          Please understand that we are not talking about vitamin deficiency simply being replaced. We are talking about disease as a manifestation of energy deficiency in our cells, particularly in the brain. Hence, the symptoms vary according to the distribution of the energy deficiency. Vitamin B1 and all its colleagues are being used as “drugs” in large doses in an effort to enable the cells to build up their energy profile. We have recognized that giving the vitamins by mouth may not reach the concentration required in the cell. By using all the water soluble vitamins intravenously, we are providing a large concentration of the “drugs”.
          Intravenous Lipothiamine
          Yes, it is available. It is made by Takeda Biochemicals in Osaka Japan. It is not recognized in the United States by the FDA but I had an independent investigator license for many years and have used it on many patients, as well as writing about it in the medical literature (again that has to be read). It has incredible value as a therapeutic agent because it addresses the core issue of disease, defined as “The Diseases of Adaptation” (Selye H, 1976).
          BCG for Fibro
          I do not know what “Fibro” stands for. I have to presume that it is being regarded as a disease of “failed immunity” and the BCG is presumably being used to stimulate immunity. If I am right it will not work!
          Lastly, what Dr. Marrs and I are essentially saying is that disease is a result of energy deficiency affecting cellular function in the brain. We regard thiamin as an important therapeutic agent because of its place in energy metabolism. There is a tremendous amount of evidence in the medical literature that thiamin deficiency can be precipitated in stressful situations such as cancer, following surgery and in chronic degenerative diseases. Ask your “Doubting Thomas’s” to research the literature.It seems incongruous that we have been able to report two children with febrile lymphadenopathy (sore throat, swollen neck glands and fever) and another child with chronic asthma who responded to megadoses of thiamin. It is this kind of experience which has suggested to us that the present medical model is a catastrophe

          Selye H. The stress concept. Can Med Assoc J 1976, 115(8):718

          1. The Healthcare model in this country is a castrophe. 5 minute consults with quick, dirty, and repetitive/lucrative big pharmachemical prescriptions…is capitalism at its worst. Prescribing something that numbs symptoms but doesnt cure, that most likely will give you something else, that you need another med for, is healthcare desguised as greed. I just think you can’t have true healthcare that is capitalistic in nature. Greed can have no part in this. The goal should be health not wealth. But there is less wealth if everybody is healthy, so you have what we have today. Now you think a deal could be struck in one of the wealthiest countries in the world. Where the best capitalistic system supports the best socialistic healthcare system. Because if you don’t have your health, what point is wealth? But perhaps I’m missing something here, maybe wealth is buying real healthcare today? When a billionaire can have fearless unprotected sex with a porn star and a playmate in the same weekend (every weekend) and still be well enough to become president… leads me to believe there is more going in healthcare than what meets my equal treatment for all eye. Enough of the stinking politics…on to the good stuff- Science!

            Takeda Biochemicals is now Takeda Pharmaceuticals….they have Japanese division and a US division. The US site only mentions pharmcueticals they offer, where as the Japanese site list supplements too….interesting. There they have a product called Alinamin which is b1 from Fursultiamine(?) and other B’s, plus vit E. Says it treats eyestrain, stiff shoulder of 50 years of age(love the Japanese), pains of the waste and lower back, neuralgia, and numbness of extremities….hmm sounds like dry beriberi and say…. fibromyalgia!…. all symptoms I have.

            The Personality and The Chasse….but within that Chasse lies what fuels that Personality …the gut. Wouldn’t you say ? Hypocreatties was and is still right. Really a symbiotic relationship between the two working to control everything. If there are bad weeds(bacteria’s, yeasts, virus’) in either and in the wrong places trouble arises. We really need GastroNeurologists. There is a functional doctor named Allison Siebecker of the Natural University of Natural Medicine that treats SIBO naturally. She may be one that would by into your thiamine theory and have the lab resources to properly test it perhaps? I sent an email about your book/theory to Dr Mark Pimentel’s( dr sibo) lab at Cedars-Sinai and never heard back. We need somebody to do the proper testing!…..not tied to big pharmachemical !!

            From EpicGenetics ( ones with FM/a fibromyalgia test and possible BCG treatment)…”Fibromyalgia is a misnomer. The disease process is neither a fibrous or a muscular disorder. The disease should be called the immune dysfunction or suppression disorder. Critical white blood cells within the body’s immune system which are peripheral blood mononuclear cells lack the capacity to produce adequate and normal quantities of vital the proteins Chennokines and Cytokines.”
            What says Dr Lonsdale about this…any experience giving BCG, it’s no longer given in US for some reason, yet schools quarantine kids suspected of TB.

            Odds and ends…I have two friends one with MS(was an alcoholic) and one with dystonia(is an antibiholic). Has thiamine therapy shown to reduce MS plaques or treat dystonia in any way? Using oral or IV therapy? On a personal note I was told to stop supplementing with magnesium because my levels were too high on an interacelluar blood test. You say one has to take magnesium when taking thiamine, in my case would I not take it alongside the lippothiamine ?

            The End…Happy Easter Dr Lonsdale and thanks for your continued guidance & knowledge

  6. Very good way to refute the accusation. I did a little detective work. This same “reviewer” left a similar review for Benfotiamine product on iHerb in 2010. I would guess from the number of reviews this person made around that time, that there could have been an adverse reaction to the multiple products potentially being used and blamed it on the Allithiamine. I saw this review when I ordered my Allithiamine months ago, so your explanation was of great interest to me.

    The note about TTFD helping to protect against carbon tetrachloride toxicity in the liver could be very helpful to my illness, as a secondary benefit! Thank you, again!

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