A Kindled Brain: Long Term Lexapro Use Reactions

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lexapro kindling
One year ago, I was living the American dream, a father of two young sons, active, social, traveling sales person. All of that was taken away from me because of a pill. I never had any history of mental illness or even anxiety for that matter. I “sold myself to the devil” as they say by taking a medication that I was told would help me with some fears with public speaking. I am now paying the price for that decision.

Fearless and Careless on Lexapro

I was always the social person. Class clown, outgoing and had a lot of friends. I wasn’t the best student but because of my outgoing personality, sales was a no brainer for a career. In late 1990’s in early 2000’s most of my friends (including me) were getting married. I was often asked to be the best ma. I noticed I was uncomfortably nervous during those speeches. I also noticed I would often experience this feeling during my work presentations. Plus, I had a fear of flying on airplanes which was a job requirement. I decided to talk to my doctor about it and he suggested a psych. I went to see the psych for only three weeks but he changed the course of my life with just a couple of strokes of a a pen on a piece of paper. This doctor prescribed a pill. A pill that many say “re-wires” the brain. The medication he suggested was Lexapro. I had never heard of Lexapro, but back in 2001, anti-depressants were taking off.  You may recall the TV series, The Sopranos.  It was a hit cable series that featured characters that as soon as anyone had any issue pop up, the doctor prescribed an antidepressant. It seemed to me that they were making a joke of the concept that everyone on the show needed a medication to function.

In 2003, during the peak of that wave, I started Lexapro. Within weeks, I was transformed into someone who feared nothing. Everything became much easier for me. I could present to large audiences. My fear of flying disappeared. My career took off. I became even more social, feeling confident in any setting. I enjoyed being the center of attention. I then started making changes in my life. I got divorced. At the time, I felt that I did not need to put up with anything if I didn’t want to. It was hard, as I had two young sons, but I felt it was the right move for me at the time. Looking back it was a cold move (and I handled it poorly) but I was laser focused on what I wanted to do. I became much more comfortable and flirtatious with women (not in an obnoxious way). At the time, I wanted to be free. In so many ways, in my mind, I was an improved person. It wasn’t until the last year that I realized how wrong I was. I took Lexapro for 15 years. I never looked back. Until now.

The Slow Build up of Symptoms: Lexapro Rejection

Fourteen years later, after living quite a normal, active life, I began to struggle with my health. I had a girlfriend (an angel-she’s been by my side throughout), two wonderful sons (now 13 year old twins). However, in the beginning of 2015 I started having a lot of dizziness, stomach issues and low sodium counts in my labs. I was diagnosed with IBS. In addition, doctors thought I had a stroke in one trip to the ER. The possibility of a stroke was  was supported by a CT scan but then later overruled by an MRI. They diagnosed me with a TIA (mini stroke), but I didn’t buy it and carried on with my life. It wasn’t until later that I realized my body was rejecting Lexapro.  In June 2015,  after several months of continued low sodium counts in my blood and dizziness,  my doctor suggested I come off Lexapro. In late November 2015, being off Lexapro for 5 months,  I was improving slightly. However, I was growing impatient with my improvement and was also was planning on starting a new job in January 2016. I wanted a quick fix and wanted to be “grounded” for the job I was so excited for. I went to my doctor and he suggested going back on Lexapro.

A Kindled Brain

The first pill I took something seemed off. There was a burning feeling in my head along with a headache. I started to feel some increased anxiety as a result. My brain felt impaired. I don’t recall this feeling at all during my first go-around with Lexparo. I called my doctor and he said all of this was normal. Increase the dose. I did as I was told.

The burning increased. The head pressure feeling I had was horrific. I was scared. I called my doctor and this time the nurse said he was very frustrated with me. He said not to go off the Lexapro. That these were normal symptoms. I disregarded his suggestion and I went off the medication. The reinstatement was eight days in total. For the next three weeks, I dealt with horrible dizziness, head pressure, and confusion. For example, I backed my car out of my garage before it was finished opening, taking off my antenna and knocking the garage door off the track. My life was falling apart. I was excited to start the new job, but was now nervous I would not be able to do it due to my health.

The Lexapro Firestorm

Then Christmas Day came. The day my life completely crashed. I woke up with cognitive impairment, anxiety, and fear. I later found out the fear, anxiety, stress emotions are controlled in a part of the brain that the medication touches. I knew it was serious and from that point forward, I would never be the same. It was an electric, chemical feeling that was relentless. I was so wired with stress, that severe insomnia set in. After a few days, I went to my doctor, and at this point, he was tired of me. He called me a “complex case” and suggested I go back on Lexapro and suggested I see a psychiatrist. The last time I saw a psychiatrist was 15 years prior for the 3 weeks when I was put on Lexparo for “meeting nervousness.” I reluctantly went. She felt I was making up the symptoms in my head. She would not be the first person to tell me that. She also suggested I go back on Lexparo as well.

I went on disability with my current employer. I continued to decline. I went to dozens of doctors. No one understood. Some felt bad for me. Some said that meds could cause adverse reactions but no one would commit. Some thought just because it was an anti-anxiety med I had a problem with my mental health or I may be making up my symptoms. With no history of mental illness at 49 years old someone who is living the American dream comes up with a mental disorder overnight, the same week of reinstating a medication that is proven to rewire the brain, is it coincidence? I don’t think so. The chemical anxiety and head pressure did leave my system within weeks of stopping Lexparo, which was proof to me that this wasn’t in my head as suggested by some doctors and that it was caused by the medication. However, fatigue did set in, I imagine, due to the stress of all of this. I was eventually diagnosed with Chronic Fatigue and then Fibromyalgia.

One Year Post-Reaction

I wish this story had a happy ending. It is now December  2016 and the fatigue has worsened to a point where I am mostly bedridden. Watching TV is difficult. Luckily, for all you readers, I can still type. After months of frustration of getting limited knowledge of medication reactions, I started researching. I also discovered mitochondrial damage and neurotoxicity. From what I understand, it can happen from infections, chemicals and medications. I have found many like me who have had reactions from anti-anxiety and antibiotic medications, as well as vaccines. I am optimistic as I am currently having a dialogue with a neuropsychologist that actually believes in and helps victims of neurotoxicty. She seems to be in my corner which I’m grateful for. Its a lonely feeling being in this position. I also bumped into Dr. Marrs’ article on Orexin destruction from adverse reactions . I think this is may have been what has happened to me. The physical fatigue is one thing but the mental fatigue/sleeping pill feeling is what is the most disabling.

Based on the research, it is my theory, that I have had an adverse reaction or “kindling”. A kindling is a reaction or stimulus that causes agitation or anxiety, stimulating the brain for a period. Once the chemical (in my case, Lexapro) source is removed, the stimulation will eventually reduce, and the person, more than likely, will be left with severe mitochondrial damage. I wake up daily feeling as if I never slept; more tired than when I went to bed. I struggle to read or follow TV because of the impairment.

My lifelong dreams may be over or at least on hold for a while. When I explain to people what has happened to me they can’t believe someone’s life can be turned upside down by a pill. I am shocked that of the thousands of people I know in my situation, doctors do not know how to either diagnose of treat them. Instead, we are diagnosed with CFS or depression. What I am most shocked about is how doctors can prescribe these pills without understanding what they  do to the brain. Part of me feels this is “karma” as they say — like I sold my soul to the devil to take a pill that would improve my life in many ways, but ultimately, it destroyed me. I pray for a happy ending.

Articles suggest that people with TBI’s often end up with low orexin/hypocretin and excessive sleepiness. Articles suggest that people with suicidal depression often have low orexin. They also say that stress causes orexin deficiency. These same articles, as well as Dr. Marrs’ work, suggests that these levels can improve, by removing stressors and properly repairing mitochondrial functioning. I want to thank Dr. Marrs for allowing me to write this and share my story with you. I hope I didn’t frighten anyone with my story. I doubt “Dateline” or “20/20” will be coming to my house to interview me in the near term, but I do think there will be a day that there will be more public awareness of the damage medications can cause to the body.

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    1. I have been on lexapro for around 9 years and recently came off about 6 months ago. Have been experiencing some ups downs but I’m still medication free. Really don’t want to go back on anything at all. I thought my discontinuation was pretty successful, but am concerned of the long term effects. Looking to connect with someone on here if possible an emaa

  1. I hope you frightened a whole lot of people with your story because after 26 years of specializing in antidepressant adverse reactions I am really sick of hearing this same story over and over and over again with only the name being changed. Welcome to typical cold turkey antidepressant withdrawal. This is why at the top of our websites for two decades we have posted: “WARNING! Discontinuing or changing an antidepressant abruptly can be more dangerous than continuing on the medication.”

    You will be interested in learning several things about SSRIs. First is that they drastically increase Cortisol. A study done by Lilly on Prozac found that one single 30mg dose clearly DOUBLED the level of Cortisol! I have been shouting that warning via my book, “Prozac: Panacea or Pandora? Our Serotonin Nightmare,” radio and television interviews, blog after blog, etc. for two decades. Why? Because as most know such a drastic and prolonged increase in Cortisol can produce a myriad of health issues including depression – the very indication for which these drugs are given! They are literally causing what they are being promoted to cure!

    You are correct about kindling which I also discuss in my book on this family of antidepressants. You will find many answers on our website at http://www.drugawareness.org where my dear friend Dr. Candace Pert served on our Board of Directors from 1997 when she publicly referred to these drugs as “monsters” she wished she had never had anything to do with their development until her death three years ago. You will want to read more about her there.

    We also have several Facebook groups you will be interested in: “Lexapro Should Be Illegal,” “Antidepressant-Induced Fibromyalgia,” “Antidepressant-Induced Adrenal Fatigue/Failure”

    We also have many alternatives we have found over the past 2 1/2 decades which have proven to be quite helpful in rebuilding and even in reversing the brain damage that can come from antidepressants.

  2. Hi CF, Thank you for your honest story. I left my marriage to a loving man in the same way you describe, while numbed out from benzodiazepine. I didn’t realize my massive mistake until I discontinued the drug. I am very active in the pharma injury community. Find me on FB. I shared your story today and it has sparked a big discussion you may be interested in. It takes time to heal from a CT (cold turkey) and further kindling from a reinstatement. Give it time and support your body comprehensively to assist the brain’s healing. You are surely not alone in this agony.

  3. Thank you for writing your story. I especially could relate to these lines: “At the time, I wanted to be free. In so many ways, in my mind, I was an improved person. It wasn’t until the last year that I realized how wrong I was. I took Lexapro for 15 years. I never looked back. Until now.”

    For me it was 17 years. It is criminal to take someone’s life like that and destroy it. Looking back and realizing the destruction left in the wake of psychotropic medications. This is providing me with a cruel enlightenment of lost decades and the recognition of the emotional devastation to those we love but wasn’t able to.

  4. I found your article very interesting considering I just had neurotransmitter testing and a brain scan called a NeuroRead processed by evoke neuroscience. I got this done totally on my own by a doctor I had never met or heard of because I was getting no place with my own doctors! Now she’s treating me with supplements to heal my brain because I do have brain damage. So you might look into it? Evidently I’m producing too many antibodies in my brain.

    1. Hi, you could help us by telling us what kind of blood test did you do exactly for show antibodies in your brain? And what kind of supplements do you take for heal your brain? Do they help in any symptom?

      I also suffer from brain damage caused by only 11 pills of escitalopram poison which I took almost two years ago.

      Thanks for your help!

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