Oxygenation: Key to Health or Disease
The major message is that the normal delivery of oxygen and its use in respiration within cells is vital to complete health, resting heavily on the pioneering work of Dr. Otto Warburg. Most of us give little thought to what we do with the oxygen that we extract from the air by breathing. We are aware, of course, that oxygen is picked up by the hemoglobin in our red blood cells. The action demands an intricate biochemical transfer of oxygen from the lung alveoli to those cells. They then travel in the blood stream to all our body tissues and another complex reaction transfers oxygen from the red blood cells to the cells that make up all our tissues and body organs. This transfer mechanism depends on the health of the cell membrane that is at least partly dependent on the ingestion of the vital omega-6 and omega-3 polyunsaturated fatty acids (PUFAS).
Our cells, and we have between 70 and 100 trillion of them, have an extraordinarily complex structure. Each one, with the exception of red blood cells, has a nucleus, surrounded by a fluid called cytosol. The outer membrane of each cell, known as the plasma membrane, represents a potential barrier to the transfer of nutrients, including oxygen, from red blood cells to the cytosol. Oxygen, vitamins, and essential minerals then have to cross the membrane around the nucleus where respiration gives rise to an energy storage molecule called adenosine triphosphate (ATP). If this transfer is not complete, respiration declines and the cell uses fermentation in the cytosol to synthesize ATP.
This essential transfer across membranes depends on what is known as fluidity. The nearest that we can get to describing cell membrane function simply is that they require fluidity similar to the fluidity in a soap bubble, but much more complicated. Omega-6 and omega-3 PUFAS are essential oils obtained from ideal nutrition and they help in maintaining this fluidity, enabling oxygen transfer and absorption of cell nutrients to take place.
Oxygen, the primary nutrient, then has to be consumed in the process of synthesizing ATP. It is, of course, useless to have oxygen transferred into cells if it then remains unused. The fuel that is burned (oxidation results from the combination of oxygen with a fuel) in this process is glucose and one of the vital components is vitamin B1 (thiamine), a nutrient that I have emphasized repeatedly on this forum. Deficiency of this vitamin, together with an excess of simple carbohydrate, causes the ancient scourge of beriberi.
One of the known factors in this disease was reported by Japanese investigators many years ago. They found that the oxygen saturation of arterial blood (on route to body tissues) in beriberi victims was very low. The venous oxygen saturation was very high (blood returning to the lungs for oxygenation). This means that the pickup of oxygen at the lung was poor and it was transferred to the venous circulation without doing its job in the cells. It is therefore possible that long term, low grade thiamine deficiency could well be the forerunner of cancer.
Thiamine, Cancer, Diabetes and Neurodegeneration
Recently it has been found that low dose administration of thiamine stimulates cancer cells in an animal model, while very high doses inhibit their growth. Diabetes type I is pancreatic insulin deficiency. Type II is insulin resistance. Alzheimer disease is associated with glucose metabolism and may be diabetes type III. Cancer may turn out to be diabetes type IV. Reading between the lines, it looks as though thiamine metabolism is a key factor in causing many diseases because of its role in oxidation. This information is also important in understanding why malnutrition, particularly involving an excess of sugar, as is common today, is causing so much functional change in millions of people.
The so-called psychosomatic symptoms are often due to the early stages of beriberi, a disease where changes in the control mechanisms of the autonomic nervous system have long been known to occur. Thus the reduction of normal oxygenation and oxidation in the production of cancer is emphasized and it may well be that we can extend the principle to the cause of many different diseases. The brain is the most oxygen consuming organ in the body so that even minor deficiencies of oxidation can affect its performance. Since the lower brain contains the mechanisms of automatic control of the autonomic endocrine axis, it could explain why so many publications in the medical literature report an association of autonomic nervous system dysfunction with a variety of organic diseases that are so common in our world today.
Considering Malnutrition in the Presence of Abundance
A little history may help us to understand why various forms of malnutrition are so easy to neglect when we fail to follow the rules set by Mother Nature. Beriberi often broke out in Japan when there was increased affluence. The reason was really quite simple. Brown rice is the full grain and the vitamins needed for processing the starch are stored in the cusps around the grain. White rice is produced by milling the cusps off the grain and this was performed at a rice mill, a relatively expensive procedure for many people. The cusps were given to feed pigs and it is paradoxical that the pigs were better fed than the humans. White rice was therefore considered to be a marker of affluence and caused many people to set the milled rice in a silver bowl and invite their friends to dinner. They did not realize that they were inducing the common dread illness that they all knew about.
Can we take a leaf out of their book and compare our affluence of today with what happened in Japan years ago? Sugar and simple carbohydrate are dangerous commodities that may well be one of the commonest causes of disease in Western civilization. Consider this together with the absence of appropriate PUFAS and other essential nutrients and we cannot deny that malnutrition is today very much alive and well.
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