vitamin d

Vitamin D’s Role in Preventing and Treating Multiple Sclerosis

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Modern lifestyles are countering nature’s intentions to keep us healthy. Since the advent of the Industrial Revolution in the late 18th century, we have migrated from farms to factories and office buildings. Nature intended for us to live and work outdoors in the sun—without sunscreen. Today most of us live and work indoors—often wearing sunscreen, or cosmetics containing sunscreen. By doing so, we have denied our bodies one of the most fundamental sources of health: the ultraviolet B (UVB) rays of the sun that initiate vitamin D protection in our skin.

Compelling scientific evidence over the past century indicates the significant role vitamin D plays in protecting us from developing a wide variety of medical conditions including autism, autoimmune disorders, cancer, cardiovascular disease, diabetes, and thyroid disorders. It is not a coincidence that the prevalence of these diseases has emerged during “modern” times. These medical conditions, many of which are serious, chronic, and life-threatening, frequently result in health, financial, and social burdens to the patients and their families.

What is Multiple Sclerosis?

Multiple sclerosis (MS) befits a disease of modern civilization. First identified by French neurologist Jean-Martin Charcot in 1868, MS is a chronic, neurological autoimmune disorder that damages the myelin sheath, the multiple layers of fatty tissue that surround and protect the nerves in the brain, spinal cord, and optic nerves. When the myelin sheath is intact, electrical impulses are carried through the nerves with accuracy and speed. When the myelin sheath is damaged (sclerosis is the scar tissue formed by damaged myelin), the nerves do not conduct electrical impulses normally. The impulses are distorted or interrupted, resulting in a range of symptoms including numbness, blindness, paralysis, and brain damage. MS also can result in death.

Who is at Risk of Developing MS?

Despite the identification of MS almost 150 years ago, MS has no cure. Over 2.5 million people around the world have been diagnosed with MS including about 400,000 Americans. Women are to two to three times more likely to develop MS than men. Although MS is usually diagnosed between the ages of 20 and 50, the disease can strike at any age. In addition, Caucasian women of Northern European descent are more frequently diagnosed with MS than African Americans, Hispanics, and Asians.

As part of the Environmental Risk Factors in MS Study (EnvIMS), researchers at the University of Bergen in Norway sought to understand better the association between MS and sun exposure measures by studying a total of 1,660 MS patients and 3,050 controls from Norway and Italy. The researchers’ findings included significant connections between infrequent summer outdoor activity and sunscreen use and an increased risk of MS. Published in the January 10, 2014 issue of Multiple Sclerosis, the study’s conclusion stated, “Converging evidence from different measures underlines the beneficial effect of sun exposure on MS risk.”

It is not surprising that incidences of MS in the equatorial region occur much less frequently than at the higher latitudes. Epidemiological studies over the past several decades however indicate that women who live at higher latitudes have an increased risk of developing MS. For example, University of Oxford researchers studied MS patterns in Scotland by examining hospital admissions throughout the country between 1997 and 2009. The research team discovered a “highly significant relationship between MS-patient-linked admissions and latitude” across Scotland. This study was published in a 2011 issue of the Public Library of Science (PLoS) One journal.

In addition, a seasonal risk factor also exists for MS. Researchers at Queen Mary University of London conducted a systematic review of data for 151,978 MS patients to ascertain the link between month and location of birth, and the risk of developing MS. They found that babies born in April had the highest risk of development of MS, and infants born in October enjoyed the lowest risk of MS. The researchers also noted a direct correlation between the latitudinal location of expectant mothers and MS risk. The study, published in a 2012 issue of the Journal of Neurology, Neurosurgery, and Psychiatry, suggests the importance of maternal vitamin D supplementation in particular during the winter season.

What Causes MS?

The definitive cause of MS remains unknown but medical research suggests genetic and environmental factors influence one’s risk of developing MS. Interestingly enough, science has demonstrated that vitamin D plays a role in influencing environmental and genetic factors that may affect how likely one is to develop MS.

A landmark study at the University of Oxford, published in a 2009 issue of Public Library of Science (PLoS) Genetics, examined how genes and the environment interact in MS. A gene variant called HLA-DRB*1501 is associated with an increased risk of developing MS. The research team discovered how vitamin D influences the HLA-DRB*1501 gene variant. As we know, the amount of vitamin D synthesized by UVB sunlight exposure fluctuates from season to season. Therefore, women who give birth during the spring, carry the HLA-DRB*1501 gene variant, and have low vitamin D levels are more likely to produce children with a higher risk of developing MS.

The study’s author Dr. Sreeram Ramagopalan suggested that adequate vitamin D3 supplementation during pregnancies may decrease the risk of children developing MS in later life. The combination of carrying the HLA-DRB*1501 gene variant and lacking adequate vitamin D levels may impair the ability of the thymus, an immune system organ, to delete rogue T cells, a type of white blood cells, that play an important role in maximizing the immune cells. The rogue cells would attack the body, causing demyelination of the central nervous system.

How Can Vitamin D Protect Against MS?

MS is a neurological autoimmune disorder. Scientific research over the past few decades solidifies the connection between vitamin D and autoimmunity. Vitamin D plays an integral role in the regulation of the adaptive immune system.

Adequate vitamin D in our bodies can protect us from autoimmunity because adaptive immune cells contain vitamin D receptors (VDRs). These receptors are attached to the surface of the adaptive immune system’s antibodies and sensitized lymphocytes. When the VDRs receive adequate amounts of vitamin D, they enable the adaptive immune system to function properly by attacking new and previous invaders.

When the VDRs attached to the adaptive immune system’s cells do not contain sufficient vitamin D to attack invaders, autoimmunity may kick in, causing the death of healthy immune cells. Thus, vitamin D deficiency can contribute to the development of autoimmune disorders such as MS.

How Can Vitamin D Treat MS?

The scientific community is delivering hope to MS patients by investigating vitamin D intake as a treatment for the disease. Research suggests that higher vitamin D levels are associated with reduced disease activity in MS sufferers.

Dr. Alberto Ascherio of Harvard University’s School of Public Health and colleagues recently concluded that vitamin D appears to be connected with MS disease activity and progression in patients who experienced an initial episode suggestive of MS and were treated with interferon β-1b. The researchers found that 20 ng/mL-increases of vitamin D levels within the first 12 months of experiencing an initial episode predicted a 57 percent lower rate of new active lesions as well as a lower risk of relapse. In addition, the results included a 25 percent decrease in annual T2 brain lesion volume and a 0.41 percent lower yearly loss in brain volume over four years. The Harvard study was electronically published on January 20, 2014 in JAMA Neurology.

According to a study published in a 2012 issue of the Annals of Neurology, a University of California, San Francisco research team examined 469 male and female MS patients over five years to ascertain how vitamin D affected disease progression. The researchers discovered that for each increase of 10 ng/mL in vitamin D levels, the MS patients benefited from a corresponding 15 percent decrease in new brain lesions as well as a 32 percent lower risk in inflammation of the myelin sheath.

A Finnish study, published in a 2012 issue of the Journal of Neurology, Neurosurgery, and Psychiatry, concluded that vitamin D3 supplementation significantly reduced the number of brain lesions in MS patients undergoing interferon β-1b treatment.

Paving a Way to Better Health and Quality of Life

Adequate vitamin D levels in our body may indeed protect us from developing MS. If you have experienced a possible initial episode or have been diagnosed with MS, please consider how vitamin D3 supplementation may decrease the severity of your symptoms.

We must take ownership of our health by understanding the importance of vitamin D as well as other micronutrients. Why wait years, or decades, to garner the results of further studies and clinical trials to define the exact relationship between vitamin D status and MS. We can be proactive by taking daily vitamin D3 supplements and enjoying moderate sunlight exposure to increase our vitamin D levels.

It is imperative to take enough vitamin D so this essential nutrient will be stored in your cells to help regulate your immune system. The greater your vitamin D level (easily obtained from a simple blood test called 25(OH) vitamin D), the more likely you will benefit from a stronger immune system that will protect your body’s cells from attacking one another.

No one wants to endure the health, financial, and social burdens of a chronic debilitating disease. By empowering yourself with adequate vitamin D, you may not only reap lots of health benefits but enjoy a better quality of life.

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Image credit: Stephanie021299, CC BY-SA 4.0, via Wikimedia Commons
This post was published here originally on March 4, 2014. 

Copyright © 2014 by Susan Rex Ryan. All rights reserved.

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Summer’s Best Bargain: Free Vitamin D

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The warmest season of the year is around the corner. Many of us are looking forward to school holidays, work vacations, and relaxing. And shopping often accompanies our summer fun. So take advantage of the best bargain of the season: better health – for free! That’s right, I am talking about sunshine: the light emitting from the fiery heart of our solar system. Ultraviolet B (UVB) rays from the sun provide us with an essential nutrient called vitamin D. Yes, this is the vitamin that not only strengthens our bones and muscles but may significantly protect us from a wide range of serious diseases including autoimmune disorders, cancer, contagious illnesses, diabetes, and heart disease, according to a plethora of credible medical studies from around the world.

Many people—across generations and geographical locations—suffer from low vitamin D levels from lifestyles that do not include unprotected sunbathing. Since the late 1980’s, the medical community has emphasized the need to “shun the sun” to avoid skin cancer. Consumers have embraced this advice by spending billions of dollars so they can slather chemical-laden lotions with exponentially increasing sun protection factors all over their bodies. This behavior has resulted in a vitamin D deficiency epidemic.

Moderate sun exposure is healthy for most individuals. Our bodies possess an inherent mechanism to process only the necessary intake of sun rays, about 20,000 international units of vitamin D. After our skin is exposed to direct sunlight under optimal conditions for about 20 minutes, its safety mechanism turns off the initial production of vitamin D. For many folks, it is then time to move to the shade or don additional protection to reduce the risk of sunburn.

Optimal conditions to enjoy summer’s vitamin D depend on a number of factors that we can, and in some cases, cannot control. These factors include:

Geographic location. The closer you are to the equator and the higher your altitude the better your opportunity to acquire vitamin D-rich sunlight.

Time of day. The window of sunlight between 10:00 in the morning and 2:00 in the afternoon is optimal. If your shadow is shorter than your height, you are in the potential vitamin D-producing time frame.

Sky clarity. An azure sky is highly preferable to cloud cover. UVB light is decreased by about 50 percent when penetrating clouds. Ozone pollution absorbs UVB rays before they reach your skin.

Skin. The less clothing, makeup, and sunscreen you wear, the better the odds that your skin can produce vitamin D. It also is important to understand that melanin, the pigment in your skin, absorbs UVB rays. The lighter your skin, the better chance you can make vitamin D more efficiently.

Age. Youth trumps older ages because the concentration of the vitamin D precursor in our skin, called 7-dehydrocholesterol, decreases with age.

Weight. Less weight means typically more vitamin D production from the sun. As vitamin D is fat-soluble, the body’s fat cells more rapidly absorb vitamin D, decreasing its availability to organs, tissues, and cells.

You may be thinking, “I live near sea level, far from the equator, in mostly cloudy conditions with cool summer temperatures; work full-time during the day; and am dark-skinned and overweight. How on earth (literally) can I get any measurable vitamin D from the sun?” Take advantage of sunny weather by enjoying an outdoor lunch break. Remove that hat, roll up your sleeves, and soak in the sun. Ten minutes of sun exposure is better than none.

Each individual’s options for absorbing nature’s gift of vitamin D may differ.* Fortunately, widely available sources of vitamin D including vitamin D3 supplements may be highly effective in raising your body’s D levels to protect you from a wide array of medical conditions. The information about, and benefits of, vitamin D could fill a book. In fact, I am so impressed with vitamin D’s health benefits that I recently published a book called Defend Your Life to encourage people to improve their health by taking vitamin D.

Happy summer, and happy health!

*Persons who have developed sarcoidosis, specific granulomatous diseases, and rare cancers may experience hypersensitivity to sunlight exposure.

Copyright © 2013 by Susan Rex Ryan
All rights reserved.

Image by pixel2013 from Pixabay .

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Improving Male and Female Fertility with Vitamin D

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Vitamin D is essential to a healthy life, at any stage, yet its effectiveness is often overlooked by practitioners treating parents who are trying to conceive. The overwhelming majority of infertility cases are treated with drugs or surgical procedures, and are successful less than 50 percent.

Supplementation presents a simple, safe, inexpensive, and potentially effective approach to preparing for fruitful conception. In this article, I address vitamin D’s role in reproduction, evidence supporting the positive effect of this nutrient on fertility, and how to become vitamin D healthy parents.

Vitamin D’s Role in Reproduction

The human reproductive system comprises billions of cells. Every cell in the female and male reproductive systems contains genetic codes as well as a receptor to receive vitamin D.
Vitamin D is actually a steroid hormone produced by our body. We manufacture vitamin D when we take a quality vitamin D3 supplement, expose our skin to optimal sun light, or consume lots of fatty fish or vitamin D3-fortified foods.

Cells in the female reproductive system (including the ovaries, fallopian tubes, uterus, placenta, and decidua) are replete with vitamin D receptors. The male reproductive system cells (including the testes, prostate, and urethra) also are abundant with vitamin D receptors.

When we have ample amounts of activated vitamin D, it binds with its receptor to regulate genes in our reproductive system. For example, activated vitamin D in the female reproductive system controls the genes involved in estrogen production. Vitamin D also regulates several genes during the process of embryo implantation.

Conversely, when the reproductive system lacks activated vitamin D, genes essential to conception are not expressed. Hence, the chances of achieving successful conception are diminished.

Both Mom and Dad Need Vitamin D for Fertility

For many couples, getting pregnant and carrying a pregnancy to term present daunting challenges. But few understand how vitamin D plays a role in fertility of both biological parents. Scientific research indicates that the significant prevalence of vitamin D deficiency correlates to the incidences of infertility cases in women and men:

  • Researchers in Milan, Italy conducted a study of 335 women who were candidates for in vitro fertilization (IVF). Published in the August 14, 2014 issue of The Journal of Clinical Endocrinology & Metabolism, the study demonstrated that the women with vitamin D levels of more than 30 ng/mL (75 nmol/L) enjoyed the highest chance of pregnancy. The researchers concluded vitamin D is an emerging factor influencing female fertility and IVF outcome.
  • Greek researchers recently examined 30 years of scientific literature on the role of vitamin D in human reproduction. The accumulated evidence suggests that vitamin D is significantly involved in the reproductive system of both genders. Regarding fertility, the researchers noted that vitamin D status is associated with semen quality and sperm count, motility, and morphology. Moreover, they concluded that there also is a positive effect of vitamin D supplementation on testosterone concentrations and fertility outcomes. The review was published in a 2013 issue of the International Journal of Clinical Practice.
  • An Australian fertility specialist, Anne Clark, M.D., presented findings to the 2008 Fertility Society of Australia Conference that demonstrated the role of low vitamin D in men. More than one-third of the 794 men who underwent a vitamin D blood serum test were determined to be deficient in vitamin D (as well as folate). Among the couples where the male completed supplementation treatment for nutritional deficiencies, more than one-half conceived naturally or with minimal treatment.

How to Become Vitamin D Healthy Parents

In today’s modern indoor living, the most effective source of vitamin D3 (cholecalciferol) is an oil-based soft gel or liquid supplement. Vitamin D3 supplements are available over the counter in retail and online stores. Beware of vitamin D prescriptions as most contain vitamin D2 (ergocalciferol) that is much less effective than vitamin D3.

The amount of vitamin D3 depends upon your vitamin D level, derived from a simple blood test called 25(OH)D. Assume you are vitamin D deficient (most people are) and get your blood tested by your healthcare practitioner.

Based on the results of your test, supplement daily with vitamin D3 to safely increase your blood levels. A number of vitamin D experts believe a healthy vitamin D range is at least 50 to 80 ng/mL (125 to 200 nmol/L).

Repeat the test in three to six months. Increase or maintain your daily D3 dose in response to your current level. Getting within range will take time (at least months) but rest assured that you will be gaining vitamin D wellness that should increase your chances of getting pregnant.

Vitamin D’s benefits do not end with fertility! Stay tuned for my next Hormones Matter article “Maternal Vitamin D: Pregnancy and Beyond.”

Editor’s Note: Susan Rex Ryan is an award-winning author who is dedicated to vitamin D awareness. Her extensive collection of health articles can be found on Hormones Matter as well as on her vitamin D blog at smilinsuepubs.com. Follow Sue on FB “Susan Rex Ryan” and Twitter @vitD3sue.

Hormones Matter does not provide medical advice, diagnosis or treatment.

Copyright © 2014 by Smilin Sue Publishing, LLC
All rights reserved.

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Vitamins D3 and K2: Power Partners for Mitochondrial Health

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One of the more common questions regarding vitamin D supplementation is whether or not to supplement with vitamin K also. In this post, I will address those questions as well as look into the roles of these vitamins in mitochondrial function.

If you recall your high school chemistry, mitochondria are the powerhouses of our cells. Their production of cellular energy, or adenosine triphosphate (ATP), depends primarily upon fuel derived from nutrients including vitamins D3 and K2. These two nutrients are co-factors, or partners, synergistically ensuring strong bones and teeth as well as a cardiovascular system void of lingering, plaque-induced calcium.

Why Is Vitamin D3 Important?

Adequate vitamin D3 is essential to our health and quality of life. Every cell in our body contains a vitamin D receptor (VDR). When a VDR is activated by a sufficient intake of vitamin D3, a number of good things happen. Vitamin D3’s mechanisms of action include: anti-microbial, anti-cancer, and anti-inflammatory. Moreover, scientific research suggests that vitamin D3 deficiency is connected to a wide array of serious medical conditions such as cancer, diabetes, mental health disorders as well as multiple sclerosis and other autoimmune diseases.

Due to our modern lifestyles and conventional medical practices, we tend to get little vitamin D3 from its natural source, the ultraviolet B, or UVB, light of the sun. From living, commuting, and working indoors to fretfully slapping sunscreen all over our skin, we appear intent on denying ourselves this essential nutrient.

The re-emergence in the twenty-first century of rickets, a Victorian-era disease causing soft bones primarily in children, calls to action the need for adequate vitamin D3 supplementation. As most diets are severely lacking in vitamin D3, the most practical way of getting adequate amounts of this nutrient is by taking an inexpensive daily, oral D3 supplement. My Facebook support group called “Vitamin D Wellness” provides information about an easy-to-follow protocol designed to increase D3 levels to an optimal value of 100 ng/mL (250 nmol/L).

The Importance of Vitamin K

Before discussing vitamin K2, I would be remiss if I did not mention the first form of vitamin K. Vitamin K1 is literally a vital nutrient. Without vitamin K1 our blood would not clot, and we could bleed to death. The good news is that vitamin K1 (or phylloquinone) is present in all green plants that acquire energy from sunlight. Green leafy vegetables including spinach, kale, collards, broccoli, and brussel sprouts abound with vitamin K1. Better news: vitamin K1 constantly recycles in our bodies so deficiency is rare.

Vitamin K2 (or menaquinone) however differs greatly from K1. There are two forms of vitamin K2: menaquinone-4 (MK-4) found in grass-fed animal protein including meat, egg yolk, butter, some cheeses, and calf’s liver.

A fermented soybean called natto, commonly consumed in Japan, is abundant in the more potent form of vitamin K2 called menaquinone-7 (MK-7). For those who do not want to consume soy, vitamins K2 MK-7 supplements made from chickpeas and formulated with coconut oil are readily available. My Facebook group protocol “Vitamin D Wellness” includes guidance on K2 MK-7 supplementation.

Health benefits of adequate vitamin K2 levels include potential prevention of osteoporosis, arterial plaque, and dental issues. Vitamin K2 moves calcium to the bones and teeth, as well as sweeps calcium from soft tissue lining such as arteries. Specifically, vitamin K2 activates proteins (osteocalcin and matrix gla protein) produced by vitamin D3 that facilitate moving calcium to where it belongs: the bones and teeth.

Low vitamin K2 levels are common. First, unlike vitamin K1, vitamin K2 is not recycled in the body. Second, the vitamin’s natural sources are lacking in most diets. Owing to the preponderance of industrial farming in many parts of the world, many people are low in vitamin K2. When insufficient vitamin K2 is in the blood stream, calcium can linger along arterial pathways potentially causing calcification, the process whereby calcium deposits form plaque accumulating in the cardiovascular system. These calcium deposits can cause heart disease.

The Vitality of Vitamins D3 and K2

Specific research on vitamin D3 and vitamin K2’s association with mitochondrial function remains limited yet fruitful:

Published in a 2013 issue of the Journal of Clinical Endocrinology and Metabolism, a Newcastle-upon-Tyne University, UK study led by Dr. Akash Sinha demonstrated, for the first time, a connection between vitamin D3 intake and mitochondria function in human skeletal muscles. Sinha and his team concluded that muscle function, including muscle fatigue, improved with vitamin D3 supplementation.

The positive effect of vitamin K2 on apoptosis, or natural cell death, in various types of cancer cells has been established. For example, researchers in China discovered the apoptotic influence of vitamin K2 on bladder cancer cells through mitochondrial pathway. Their findings are reported in an August 2016 edition of the journal PLoS One.

In summary, the powerful partnership of vitamins D3 and K2 is essential to mitochondrial health. By enjoying optimal daily intake of D3 and K2, you are more likely to have strong bones, teeth, and muscles as well as a calcium-free cardiovascular system. Oh, and your risk of developing cancer is diminished!

Do You Need to Supplement Vitamin D3 and K2?

Given the paucity of vitamins D3 and K2 in our diets, I think daily supplementation provides the most effective way to increase and maintain these nutrient levels. I find taking a daily dose of 10,000 iu of vitamin D3 and 90-120 mcg of vitamin K2 MK-7 soft gel capsules with or after breakfast works best for me. What an easy way to enjoy the benefits of this powerful partnership of mitochondrial nutrients!

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More people than ever are reading Hormones Matter, a testament to the need for independent voices in health and medicine. We are not funded and accept limited advertising. Unlike many health sites, we don’t force you to purchase a subscription. We believe health information should be open to all. If you read Hormones Matter, like it, please help support it. Contribute now.

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Vitamin D Plays an Integral Role in Adaptive Immunity

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Severe Adverse Reactions Include Vitamin D Deficiency and Autoimmunity

Hormones Matter researchers discovered that, inter alia, severe adverse reactions to any of the surveyed drugs trigger significant but varying autoimmune responses. Moreover, the research revealed an underlying consistency involving all reviewed drugs: vitamin D deficiency.

Vitamin D Helps Regulate the Adaptive Immune System

The adaptive immune system comprises the body’s intricate network of antibodies and special types of white blood cells (called sensitized lymphocytes ) to thwart new and previous invaders including viruses, bacteria, and drugs. When the adaptive immune system is not strong enough to endure external disruptions such as severe side effects of drugs, it can go awry by signaling antibodies and sensitized lymphocytes to attack healthy cells. This response is called autoimmunity—when the adaptive immune system’s cells do not recognize previous invaders and designate healthy cells as those invaders. In other words, the body’s immune cells attack its own healthy cells.

Scientific research over the past three decades solidifies the connection between vitamin D and autoimmunity. Vitamin D plays an integral role in the regulation of the adaptive immune system. Adequate vitamin D in our bodies can protect us from autoimmunity because adaptive immune cells contain vitamin D receptors (VDRs). These receptors are attached to the surface of the adaptive immune system’s antibodies and sensitized lymphocytes. The VDRs act as “gate keepers” by signaling what external substances, e.g., components of medications, can enter a cell. The VDRs must be replete with vitamin D to effectively regulate adaptive immunity. When the VDRs receive adequate amounts of vitamin D, they enable the adaptive immune system to function properly by attacking new and previous invaders.

When the VDRs attached to the adaptive immune system’s cells do not contain sufficient vitamin D to attack invaders, autoimmunity may kick in, causing the death of healthy immune cells. Thus, low vitamin D levels can lead to autoimmune diseases including thyroid disorders such as Hashimoto’s and demyelinating diseases including multiple sclerosis (MS).

Vitamin D and Hashimoto’s Autoimmune Thyroid Disease

The Real Women, Real Data research also uncovered another consistency among severe adverse reactions to the reviewed drugs: Hashimoto’s thyroiditis, an autoimmune disease caused by abnormal cells constantly assaulting the thyroid gland
.
Vitamin D receptors are present in the thyroid as well as the pituitary, the pea-shaped gland that controls the thyroid. Not surprisingly, low levels of serum vitamin D have been linked to Hashimoto’s thyroiditis, according to recent Turkish medical research:

Published in a 2013 issue of the journal Endocrine Practice, a study conducted at a training and research hospital in Ankara demonstrated that serum vitamin D levels of female chronic Hashimoto’s patients were significantly lower than healthy subjects. Furthermore, the researchers discovered a direct correlation between serum vitamin D levels and thyroid volume as well as an inverse correlation to the antibodies involved in the thyroid.

Researchers at Medeniyet University’s Goztepe Education and Research Hospital in Istanbul learned that 92 per cent of their 161 Hashimoto’s thyroiditis cases had serum vitamin D levels lower than 30 ng/mL (12 nmol/L), a value characterized as “insufficient.” Published in a 2011 issue of the journal Thyroid, the study reports an association between vitamin D insufficiency and Hashimoto’s thyroiditis.

Vitamin D and Demyelinating Disorders

Another disturbing outcome of the Real Woman, Real Data research is the reporting of neurological and neuromuscular symptoms, many which of are consistent with demyelinating disorders such as MS, an autoimmune disease. The development of MS occurs when a poorly functioning, adaptive immune system gradually attacks the protective covering of the nerve cells (called the myelin sheath) of the brain and spinal cord. This potentially debilitating process is called demyelination.

Scientific—primarily epidemiological—research indicates an association between vitamin D levels and the risk of developing a demyelinating disorder such as MS. VDRs exist on nerve cells and the myelin sheath. When the VDRs receive adequate amounts of vitamin D, they help protect the integrity of the myelin sheath. However, when the VDRs do not contain sufficient vitamin D, autoimmunity may occur, resulting in the death of healthy nerve cells. Numerous clinical trials are underway to assess the connection between vitamin D status and the likelihood of developing demyelinating disorders.

Low Vitamin D: The Chicken or the Egg?

The connection between low vitamin D status and the development of autoimmune disease is genuine. However, medical research has not yet determined if vitamin D deficiency plays a role in the development of autoimmune disease, if low vitamin D levels are a consequence of the disease itself, or if vitamin D deficiency acts as both a cause and effect. The authors of the aforementioned 2013 Hashimoto’s study concluded,

“Finally, our results suggested that there may be a causal relation between vitamin D deficiency and development of Hashimoto’s thyroiditis. On the other hand, there might be a possible relation between severity of vitamin D deficiency and progression of thyroid damage. However, further studies are needed especially about the effects of vitamin D supplementation on prevention and/or progression of autoimmune thyroid disease.”

Proactive Protection against Severe Adverse Reactions

We could wait years (or decades) to garner the results of further scientific studies and clinical trials to define the exact relationship between vitamin status and severe adverse reactions to vaccines and medications that culminate in autoimmune disorders. Or we could be proactive by taking daily vitamin supplements and enjoying moderate sunlight exposure to increase our vitamin D levels.

It is imperative to take enough vitamin D3 so this essential nutrient will be stored in your cells to help regulate your immune system. The greater your serum vitamin D level (easily obtained from a simple blood test called 25(OH) D, the more likely you will benefit from a stronger immune system that protects your body’s cells from attacking one another.

No one wants to endure severe adverse reactions to drugs such as Gardasil and Lupron, let alone an autoimmune disease. Attaining and maintaining adequate supplementation provides a safe, easy, and inexpensive approach to improved preventive health. By empowering yourself with adequate vitamin D, you may reap the benefits of avoiding disease and enjoying better quality of life.

Copyright © 2013 by Susan Rex Ryan. All rights reserved.

This article was published previously on Hormone Matter in September 2013.

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Decreasing Dysmenorrhea: High Dose Vitamin D to Reduce Cramps

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Women endure menses for an average of 40 years: once a month for 12 months for four decades—about half of our lives. Menstrual cramps (dysmenorrhea)—to varying degrees of discomfort—are also likely to occur in about 50 percent of reproductive-age women. The cramps are caused by contractions that occur in response to elevated levels of prostaglandin (fatty acids made prior to menses) in the uterine lining. Some over-the-counter and prescription drugs may alleviate these painful cramps, but why must women tolerate menstrual discomfort? Are menstrual cramps an inevitable fact of life?

Can High Dose Vitamin D Reduce Menstrual Cramps?

It is no surprise that a small medical study published in the Archives of Internal Medicinehas garnered a lot of attention around the virtual globe. Italian researchers at the University of Messina investigated the effect of mega-dose vitamin D3 on women who had experienced at least four consecutive painful menstrual periods in the previous six months and had low, circulating vitamin D3 levels. The 60 women enrolled in the study were divided into two groups. Five days prior to the anticipated start of their periods, 30 women were administered a single oral dose of 300,000 IU vitamin D3; the other half received a placebo. On the fifth day of the study, both groups commenced daily supplementation of calcium (1,000 IU) and vitamin D3 (800 IU). After two months, average pain levels decreased by 41 percent for the women treated with mega-dose vitamin D3.  No difference in pain was reported in the placebo group. The researchers concluded that their data support the use of vitamin D3 to reduce menstrual cramps.

The Italian study itself is remarkable because it is reportedly the first research conducted to understand the effectiveness of a single high dose of vitamin D3 on menstrual cramps. Moreover, the outcome is logical.  Vitamin D3’s anti-inflammatory functions combined with the fact that the uterine lining contains vitamin D receptors suggest vitamin D3’s potential use to treat dysmenorrhea. Further, the 41 percent difference in experienced pain between the vitamin D3 and placebo groups is significant.

Questions Regarding Vitamin D and Menstrual Cramps

Some questions remain. The single mega-dose of 300,000 IU vitamin D3 is eyebrow-raising. It far exceeds a prescribed weekly dose of 50,000 IU of vitamin D3. The safety of a single administration of 300,000 IU is unknown. Additional research should be conducted to ascertain the upper limits and safety of such a high dose. We also do not know how vitamin D3 supplementation would improve menstrual cramps in women who maintain adequate levels of circulating vitamin D3 across the menstrual cycle. Is it simply a matter of maintaining adequate vitamin D3 that reduces menstrual cramps or is it the high dose?  Another question regards the length of time pain reductions would continue with the lone sky-high vitamin D3 dose. Even with these questions, however, the Italian study is positive and should encourage additional research on the role of vitamin D3 in treating pain-related conditions in women.

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Hormones Matter needs funding now. Our research funding was cut recently and because of our commitment to independent health research and journalism unbiased by commercial interests we allow minimal advertising on the site. That means all funding must come from you, our readers. Don’t let Hormones Matter die.

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Editor’s Note: Susan Rex Ryan is the author of the Mom’s Choice Award®-winning book Defend Your Life about the extensive health benefits of vitamin D. For additional information about vitamin D, check out our series of Sue’s articles, and visit her blog at smilinsuepubs.com.

Copyright © 2014 by Susan Rex Ryan. All rights reserved.

This post was published originally on Hormones Matter on July 30, 2014.

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Nature’s Gift: A Vitamin D3 Tan

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Since I live in a desert and visit tropical places, I am thrilled to enjoy yet another benefit of vitamin D3: a natural tan!  For many years, the sun acted as my nemesis. I was born with fair skin, blue eyes, and light-colored hair. Despite my mom’s best efforts to protect me from the sun (including lots of sunscreen lotion), our family trips to the beach usually resulted  in sunburn for me. “Lobster red” burnt skin continued to plague me following direct sun exposure until I discovered the benefits of vitamin D3. Now that my levels have reached a significant level on the testing spectrum, I noticed that my skin no longer burns! In fact, for someone as light-skinned as me, I often sport a bit of a tan, at least on my arms and face. Why the dramatic change?

Scientific studies1 over the past 17 years have indicated that vitamin D3 may protect the skin from ultraviolet (UV) sunlight damage. This occurs when adequate levels of activated vitamin D3 in the skin’s cells increase the skin’s ability to withstand UV exposure. However, when UV light strikes the skin of people who are low in vitamin D3, high levels of nitric oxide, a free radical, are released in the body, causing potential DNA damage.

Thus, a natural vitamin D3 tan can only occur when your vitamin D3 levels are optimal. How do know if your vitamin levels are adequate? Get your blood tested by your healthcare practitioner (or via reputable on-line pharmacies). The name of the test is 25-hydroxy (OH) vitamin D. A number of experts believe that a healthy level of circulating vitamin D3 is between 50-80 ng/mL. Personally, my vitamin D3 level hovers around 100 ng/mL.

So, by increasing your vitamin D3 levels through supplementation, not only will you significantly improve your overall health and well-being, you also may get a great tan!

1Feldman D, Pike JW, Adams JS. Vitamin D (Third Edition), Volume II.  Academic Press.  2011.

Author’s Note: This article, posted on Hormones Matter website, is the fifth in Sue Ryan’s series about vitamin D3.  To read other articles about Vitamin D, click Here.

Additional information about vitamin D3’s benefits is available in Sue’s book, “Defend Your Life.” Follow Sue’s commentary on vitamin D3 and other health topics on Twitter @VitD3Sue.

Copyright ©2012 by Susan Rex Ryan

All rights reserved.

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This story was published originally on Hormones Matter in July 2014.

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Vitamin D3 and Thyroid Health

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The benefits of vitamin D3 garner a plethora of glowing press these days but little information has been reported about how this essential nutrient may be associated with thyroid disorders. An alarming number of Americans—over 25 million—suffer from thyroid disease. Women are four times more likely than men to develop a thyroid disorder. The thyroid, a butterfly-shaped gland located in your neck, regulates your metabolism and affects every cell in your body. When your thyroid is not working properly, your body becomes unbalanced, potentially causing symptoms including weight gain or loss and chronic fatigue as well as autoimmune disease and cancer. Let’s look at how vitamin D3 may affect thyroid health:

Thyroid Hormonal Balance

Vitamin D receptors (VDR) are present in the cells of the pituitary, the pea-sized gland located at the base of the brain that controls your thyroid. The pituitary produces a hormone called thyroid stimulating hormone (TSH) that signals your thyroid gland to make thyroid hormone (T3 and T4). Thyroid hormone constantly circulates throughout your body, regulating metabolism. Either inadequate or excessive thyroid hormone can wreak havoc to your health, culminating in hypo- or hyperthyroidism. Understanding the regulating effects of VDR in our cells, I surmise that the amount of activated vitamin D3 in the pituitary’s VDR may be connected to the balance of thyroid hormone.

Autoimmune Thyroid Diseases

Adequate levels of vitamin D3 may protect the immune system from attacking itself. Low vitamin D3 levels have been linked to autoimmune thyroid diseases including Hashimoto’s and Graves’ thyroiditis.

Discovered one hundred years ago by a Japanese physician, Hashimoto’s disease is caused by abnormal blood cells and white blood cells constantly attacking and damaging the thyroid. About 95 per cent of Hashimoto’s disease patients are women. A study published in a 2011 issue of the journal Thyroid revealed that 92 per cent of Hashimoto’s thyroiditis cases had insufficient circulating vitamin D3 levels.

Ten times more likely to develop in women than men, Graves’ disease is caused by antibodies that overstimulate thyroid hormone production, causing hyperthyroidism. Researchers, who investigated Japanese female and male patients with Graves’ disease over a one-year period, found a high prevalence of woefully low circulating vitamin D3 in the female patients compared to the male subjects.

Thyroid Cancer

Incidences of thyroid cancer have doubled over the past four decades. The likelihood of women developing thyroid cancer is three times greater than for men. Activated vitamin D3 regulates cell differentiation, cell proliferation, and cell death. If these vital functions go awry, cancer may develop. Epidemiological studies indicate a link between vitamin D3 and thyroid cancer. Vitamin D researcher W.B. Grant, Ph.D. published a paper in a 2012 issue of the journal Anticancer Research that indicated an association between solar ultraviolet B, vitamin D3, and cancers including thyroid.

A relatively rare form of thyroid cancer—medullary thyroid cancer—originates in the thyroid C cells where a hormone called calcitonin is secreted. Calcitonin’s functions include stimulation of vitamin D3 production in the kidneys. The measurement of calcitonin is a diagnostic screening tool for medullary thyroid cancer. VDR are present in the thyroid C cells. Understanding the powerful effect of activated VDR on cell regulation, I hypothesize that activated VDR in the C cells may possibly prevent the development of medullary thyroid cancer.

In conclusion, recent medical literature suggests a connection between vitamin D3 and thyroid health. However, additional research is required to determine if thyroid dysfunction may cause vitamin D3 deficiency, or low vitamin D3 status may contribute to thyroid disorders.

Copyright ©2012 by Susan Rex Ryan, all rights reserved.

This post was published previously on Hormones Matter in September 2012.

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