Thiamine Deficiency Disease - Episode_163

Talking About Thiamine

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Do you suffer from a chronic, treatment-refractory illness that no physician or medical treatment seems to be able to fix? Are you constantly fatigued, have weak or painful muscles, or have coordination difficulties? Do you have brain fog, memory, or language processing issues? How about GI symptoms like IBS, gastroparesis, SIBO, or other dysmotility or dysbiotic syndromes? If any of these things ring true, you might have a problem with thiamine.

Thiamine (vitamin B1) is critical for the metabolism of food into cellular energy or ATP. Without sufficient thiamine, cellular energy wanes, and with it, the capacity to maintain the energy to function declines. Chronic, unrelenting fatigue is a common characteristic of insufficient thiamine. At its root, fatigue is the physical manifestation of poor energy metabolism.

Why is this nutrient such a problem? Two reasons. First, it is the gatekeeper to energy metabolism and so if it is low, everything downstream gums up and does not work well. Second, modern diets, medicines, and other chemical exposures contain numerous anti-thiamine factors that derail thiamine absorption and metabolism. This pushes many people into states of chronic deficiency, one that is simple to correct if identified. Unfortunately, however, patients can go years before the deficiency is recognized.

Last week, I had the great pleasure of speaking with Scott Scott Forsgren, FDN-P, the BetterHealthGuy, about the myriad of ways thiamine deficiency expresses itself in modern illness. If you or someone you know might be deficient in thiamine, have a listen.

Thiamine Deficiency Disease – Video Link

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To find other listening platforms, view show notes, and review the transcript, visit

And if you would like a more in-depth look at this issue: Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition.

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Chandler Marrs MS, MA, PhD spent the last dozen years in women’s health research with a focus on steroid neuroendocrinology and mental health. She has published and presented several articles on her findings. As a graduate student, she founded and directed the UNLV Maternal Health Lab, mentoring dozens of students while directing clinical and Internet-based research. Post graduate, she continued at UNLV as an adjunct faculty member, teaching advanced undergraduate psychopharmacology and health psychology (stress endocrinology). Dr. Marrs received her BA in philosophy from the University of Redlands; MS in Clinical Psychology from California Lutheran University; and, MA and PhD in Experimental Psychology/ Neuroendocrinology from the University of Nevada, Las Vegas.


  1. My husband has been put on Metformin as a cancer treatment, at the same time the Dr put him on 200mg of B1.
    He is taking 500mg Metformin and working up to 750 per day. Should the B1 go up also?

  2. Yes, I am alive and well, But I am amazed at the ignorance of American doctors. For every case report written here. there are a million people with a similar story.

  3. Hello Doc,
    I have listened to you in podcasts along with Elliot Overton. Is Dr. Derrick Lonsdale still alive? If not when did he pass away? Thank you for your amazing work.

  4. Do the anti-thiamine factors in tea and coffee, like tannins/polyphenols, have the same affect on benfotiamine s as they do on true thiamine, thiamine HCl, etc.?

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