From DES to the Pill: Are We Doomed to Repeat History?

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“The doctor wouldn’t have given it to me if he thought it was dangerous, right?”

My wife asked this salient question as we discussed the pros and cons of The Pill. It sent us both into deep reflection. Everything we read said The Pill was dangerous, but the doctor had acted like they should come in a Pez dispenser. To this day, I’m not sure where the cognitive began and the dissonance ended.

The DES Debacle: Origins of Obstinance

Doctors are generally dogmatic, but their nearly universal laissez-faire attitude toward The Pill seems particularly paradoxical when you study the scope and seriousness of its side effects. How can doctors believe that The Pill is safe, when tomes of studies suggest otherwise? Research links The Pill to everything from breast cancer and strokes, to Crohn’s Disease and lupus. To understand where we are and how we got here, it’s important to study the journey that brought us here.

By 1970, the current dogma that ‘The Pill is safe’ was well rooted in the medical community. However, enough doctors expressed concerns that Senator Gaylord Nelson decided to hold Congressional Hearings on the matter. The big three networks covered the hearings extensively, which caused great anxiety among women taking The Pill — and even greater anxiety among pill proponents, who subsequently demanded more ‘pro-pill’ doctors be included.

Senator Nelson took umbrage with their complaints, noting that all but one of the previous doctors had actually been ‘pro-pill’ to some extent, but all had reservations about its complications. Nonetheless, many of the doctors in the second round of hearings seemed more decidedly ‘pro-pill,’ including Dr. Kenneth Ryan, who stated,

I know of no information that indicates that biological properties of the estrogens used in the contraceptive pill are any different than stilbesterol for which we have at least 30 years of clinical experience…(Competitive Problems in the Drug Industry, Ninety-First Congress, Second Session, Page 6541)

Very reassuring… Unless you were actually familiar with the 30-year history of stilbesterol, also known as diethylstilbestrol (DES). Sir Charles Dodds discovered DES in 1938, and rushed it to market in the public domain. The English doctor bypassed the patent process hoping it would discourage the Nazis from further tests on women prisoners in their development of ethinyl estradiol (Barbara Seaman, The Greatest Experiment Ever Performed on Women; page 36).

From DES to the Pill

Despite his noble intentions, Dodds soon regretted the decision. Without a patent, drug companies around the globe were free to produce DES. He never expected that synthetic hormones would be given to healthy women, and was horrified that doctors were prescribing it as hormone therapy for natural menopause.

You Can’t Put the Hormones Back in the Tube

Even worse, Dodds soon learned that an American doctor named Karnaky had begun blazing a new trail – doling out DES to ‘prevent miscarriages’. Alarmed by the news, Dodds sent him a study he had personally performed, which showed that the drug actually caused miscarriages in animal subjects. It didn’t deter Dr. Karnaky or the many doctors who followed his lead. (Robert Meyers, D.E.S. The Bitter Pill; pp. 56-73)

Dodds began to feel like he was fighting a monster that he himself had unleashed. He was most concerned about how his discovery could affect certain cancers. He sent DES samples to the newly formed National Cancer Institute in the United States, and urged them to conduct tests and notify doctors.

Dodds wasn’t alone. The Council on Pharmacy and Chemistry warned,

…because the product is so potent and because the possibility of harm must be recognized, the Council is of the opinion that it should not be recognized for general use at the present time…and that its use by the general medical profession should not be undertaken until further studies have led to a better understanding of the functions of the drug. (Barbara Seaman, The Greatest Experiment Ever Performed on Women; page 44)

The concerns sent murmurs through the medical community, and many doctors began experimenting with lower doses of DES. By 1940, the editors of the Journal of the American Medical Association (JAMA) felt compelled to add theirs to the litany of warnings:

“It would be unwise to consider that there is safety in using small doses of estrogens, since it is quite possible that the same harm may be obtained through the use of small doses of estrogen if they are maintained over a long period.” (JAMA, April 20, 1940)

In 1959, the FDA determined the link to side effects (including male breast growth) was sufficient to ban poultry farmers from using DES as a growth hormone. However, the widespread use of DES in humans continued. In fact, it had become standard medical practice by the time Dr. Ryan assured Congress that The Pill was just as safe as DES – showing how medical dogma often trumps scientific evidence.

The greater irony of Dr. Ryan’s statement materialized one year after his testimony, when researchers first linked a rare vaginal cancer to the daughters of women who received DES during pregnancy. The FDA reacted strongly, listing pregnancy as a contraindication for DES use.

Consumer Groups Take the Lead

You would expect this to be the beginning of the end for DES. Shockingly, the medical community responded with indifference, continuing to prescribe DES for a variety of ‘off label’ uses, including as a morning-after pill, to catalyze the onset of puberty, and the old faithful, hormone replacement therapy. (Robert Meyers, D.E.S. The Bitter Pill; page 185)

It took nearly a decade of passionate effort from consumer movements like DES Action to convince doctors to (mostly) abandon DES. Dozens of lawsuits were filed; some were settled; and some are still pending. There is evidence that the harmful consequences could now be affecting a third generation of DES victims.

The current Director of Epidemiology and Biostatistics at the National Cancer Institute, Robert Hoover, M.D. oversees the DES Follow-Up Study to track the ongoing repercussions. With identifiable problems now affecting the grandchildren of women who took DES, the disaster hasn’t yet moved into the past tense of our nation’s history. Despite that, Dr. Hoover says:

There’s essentially a whole generation of medical students who don’t know the story. The story has such powerful lessons that I think that’s a tragedy…For about 20 years now, when I standardly ask in my general epidemiology lecture… how many of you have heard of DES, nobody raises their hand.

Sidney Wolfe, M.D., who headed up Ralph Nader’s Health Research Group offered this perspective,

DES is an excellent example of how drug companies behave, how they take advantage of the ways doctors act, and how they make millions of dollars by ignoring evidence of a drug’s harmfulness, by failing to get evidence that it is effective, and then by marketing a product that plays on fears and misconception. (Robert Meyers, D.E.S. The Bitter Pill; page 208).

In just 20 years, the American Medical Association moved from “It would be unwise to consider that there is safety in using small doses of estrogens…” to embracing the release of insufficiently tested hormones as birth control for millions of women. I’m leery of trusting a dogma founded on such an erratically moving target. In their defense, the dogma really hasn’t moved much in the decades since.

Today, the medical community assures us The Pill is the most researched drug ever. Sorry doc, that reassurance just doesn’t ring true. At this point, it feels more like a phrase learned by rote than a statement based on any kind of empirical evidence. Unfortunately, it’s not the only hollow mantra that should raise a red flag when it comes to hormonal contraceptives. I will discuss how the medical community responds to scientific studies in my next post, The Spin Doctor’s Prescription for Birth Control.

In the Name of The Pill

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Mike is an independent researcher and author, who spent much of the past decade exploring the dangers of birth control. He recently completed work on an expanded audio version of his shocking book, In the Name of the Pill.

The new version, available on Audible, examines the dubious nature of both the history and science of birth control. It features new content on modern devices and some of the little-known dangers scientists have linked to birth control.


  1. Whoops — in my zeal (and busy schedule) to post something on this Hormones Matter article to add to the breadth of the issues tied to Birth Control pills and other methods, I left out the real tragedy of Bayer’s and other drug companies’ formulas for their birth control pills — death in some cases:

    Drospirenone is a type of progestin used in combined oral contraceptives (COC) such as Yasmin, Yaz and Ocella. Owing to their unique formulation, these birth control pills — which are among the top selling brands both in the United States and abroad — have been linked to fatal blood clots and an increased risk for deep vein thrombosis, or DVT.

    Deep vein thrombosis is a serious condition where blood clots (or venous thromboembolisms) develop in the thigh or lower leg. Women with DVT are at greater risk for suffering more severe and potentially life-threatening complications including post-thrombotic syndrome and pulmonary embolism.

    While all birth control pills can increase the chance of blood clot formation, multiple studies have shown that drospirenone-containing products like Yaz and Yasmin put women at a three-fold greater risk for VTE compared to pills containing other progestins.

    Across the nation, thousands of women have claimed their deep vein thrombosis was caused by Yasmin, Yaz or their generic equivalents, and argue that drug maker Bayer failed to provide adequate warnings on potential side effects.

    Many who filed suit also suffered related blood clot injuries such as stroke and pulmonary embolism, leaving them with permanent disability, enormous medical bills and a diminished quality of life.

  2. Ahh, the new pill. And the aspirin folks, Bayer. And, Josef Mengele and his great (sic) scientific (sic) experiments (sic) —

    “Many of these experiments were in a large part sponsored by IG Farben who paid Auschwitz doctors to test their drugs on the prison victims and to discover the “secrets to heredity”. IG Farben also manufactured the cans of Zyklon B gas that were used in Auschwitz’s gas chambers. As of 1952 the company was liquidated due to its egregious war crimes and participation in Nazi Germany. Bayer was one of the four original chemical companies that survived the company’s liquidation. In 1995 the head of Bayer, Helge Wehmeier, formally apologized to Holocaust survivor Elie Wiesel for the company’s participation in Nazi Germany. The company has yet to issue a formal apology outside of that lecture.”

    Just one company peddling drugs, Bayer (and they peddle so much more, to the tune of $55 billion in 2016), which makes plastics, polymers, agricultural products, seeds and animal products, drugs, coatings and adhesives, polyurethane, is pulling in all this money on pharmaceuticals including the controversial Yaz, Yazmin, Yazminelle birth control pills. Below, 2014 side by side with 2015, in (m) millions of euros.

    Best-Selling Pharmaceuticals Products [Table 3.13.3]

    Full Year 2014; Full Year 2015 = € million
    €1 = $1.17

    Xarelto™ 2,252 m; 2,252m
    Eylea™ 1,228 m; 1,228m
    Kogenate™ 1,109m; 1,155m
    Mirena™ product family 819m; 968m
    Nexavar™ 773m; 892m
    Betaferon™/Betaseron™ 823m; 824m
    YAZ™/Yasmin™/Yasminelle™ 768m; 706m
    Adalat™ 588m; 633 m
    Aspirin™ Cardio 486m; 524m
    Glucobay™ 443m; 523m
    Avalox™/Avelox™ 381m ; 379m
    Stivarga™ 224m ;313m
    Xofigo™ 157m ; 257m
    Levitra™ 245m ; 226m
    Cipro™/Ciprobay™ 191 m ; 182 m

    Total for 2014: €9,445,000,000 m = $11 billion; Total for 2015: €11,062,000,000 m = $12 billion

    BAYER GROUP = “In 2016, we are planning sales of more than €47 billion ($55 billion)for the Bayer Group, including Covestro.”


    And we food and environment activists are concerned about “Bayersanto”, the new company descriptor that Bayer is being tagged with since Bayer bought out Monsanto last year.


    “The Bayer-Monsanto plan for farmers might look something like this: growers purchase GMO seeds (such as Roundup Ready crops), herbicides, and pesticides from the company, which uses its technology platforms to collect and analyze data on soil, weather, and plant health. Based on this data, the company then offers products and services that (theoretically) improve crop yields.

    In short, Bayer-Monsanto would be positioned to loop farmers into a system of corporate control that furthers their reliance on industrial agriculture practices. And this is supposed to be good for farmers.

    But it’s not hard to see that the corporatization of our food supply is mainly good for the bottom line of companies like Bayer and Monsanto. Big Ag has been using the same arguments for decades to justify a food system dominated by monocultures and heavy chemical use. The difference is that we now know better and are demanding healthier, more diverse, and more sustainable food.”

    When these mega corporations control markets — Amazon, Microsoft, Intel, Nike, Facebook, Google, Comcast, Bayer, Merck, Exxon, and on and on — they control so much more, including politicians, financial institutions, government agencies, markets, human and animal life, and, most importantly, education-research and the message. Controlling the message means they spend billions on PR firms, also known as propaganda firms. They put out all sorts of subterfuge on their products when citizens and independent scientists-researchers fine these products to be dangerous.

    Here, Noam Chomsky: “There’s maybe twenty percent of the population that is relatively educated, more or less articulate, that play some kind of role in decision making. They’re supposed to participate in social life either as managers, or cultural managers, like say, teachers, writers and so on. They’re supposed to vote. They’re supposed to play some role in the way economic, political and cultural life goes on. Now their consent is crucial. It’s one group that has to be deeply indoctrinated. Then there’s maybe eighty percent of the population whose main function is to follow orders and not to think.”

    We can break that mold and not follow the orders and edicts and PR and marketing and bludgeon the predatory capitalists deploy. The time has always been “to think” critically and unabashedly skeptical about anything any government or corporations puts out there.

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